The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging
The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging
复制标题
用于化学光热治疗和 X 射线成像的肿瘤靶向核壳结构 DTX 负载 PLGA@Au 纳米颗粒
DOI：
10.1016/j.jconrel.2015.11.016
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发表时间：
2015-12-28
影响因子：
10.8
通讯作者：
Zhang, Yun
中科院分区：
文献类型：
--
作者：
Hao, Yongwei;Zhang, Bingxiang;Zhang, Yun
在本研究中，通过将Au沉积到负载多西紫杉醇（DTX）的聚（丙交酯-共-乙交酯）（PLGA）纳米颗粒核的表面上，形成核壳结构的负载DTX的PLGA@Au纳米颗粒，合成了有机-无机杂化纳米复合材料。然后通过Au-S键将肿瘤靶向肽angiopep-2引入到金纳米壳上，实现具有主动靶向能力的药物递送。这种新颖的系统允许对癌症进行联合化疗和热疗法，由 DTX 和金纳米壳产生。 PLGA 纳米核周围形成肿瘤靶向金纳米壳，称为 ANG/GS/PLGA/DTX NP，其紫外-可见光谱中的表面等离子共振 (SPR) 谱带和透射电子显微镜 (TEM) 证实了这一点。该系统中 DTX 的释放曲线显示出对近红外 (NIR) 激光的强烈依赖性。与单独使用DTX相比，ANG/GS/PLGA/DTX NPs具有更高的抗肿瘤效率，且没有明显的毒性作用。此外，它还表现出了潜在的X射线成像能力。这些结果表明，肿瘤靶向核壳结构的 DTX 负载 PLGA@Au 纳米颗粒可用作具有近红外触发药物释放特性的多功能纳米材料系统，用于肿瘤靶向化学光热治疗和治疗诊断。 (C) 2015 Elsevier B.V. 保留所有权利。
In this study, an organic-inorganic hybrid nanocomposite was synthesized by deposition of Au onto the surface of docetaxel (DTX)-loaded poly (lactide-co-glycolide) (PLGA) nanoparticle cores to form the core-shell structured DTX-loaded PLGA@Au nanoparticles. The tumor targeting peptide, angiopep-2, was then introduced onto the gold nanoshell through Au-S bond, achieving drug delivery with active targeting capability. This novel system allowed combined chemotherapy and thermal therapy for cancer, resulting from DTX and gold nanoshell. The formation of tumor-targeting gold nanoshell surrounding PLGA nanocore, designated as ANG/GS/PLGA/DTX NPs, was confirmed by its surface plasmon resonance (SPR) band in the UV-Vis spectrum and by a transmission electron microscope (TEM). The release profiles of DTX from this system showed strong dependence on near-infrared (NIR) laser. Compared with DTX alone, the ANG/GS/PLGA/DTX NPs afforded much higher anti-tumor efficiency without obvious toxic effects. Besides, it also showed potential X-ray imaging ability. These results demonstrated that the tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles could be used as a multifunctional nanomaterial system with NIR-triggered drug-releasing properties for tumor-targeted chemo-photothermal therapy and theranostics. (C) 2015 Elsevier B.V. All rights reserved.