Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure
Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure
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DOI：
10.1097/01.psy.0000145821.25453.f7
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Söderström, M
中科院分区：
文献类型：
--
作者：
Ekstedt, M;Åkerstedt, T;Söderström, M
目的：以前的研究已经证明了限制睡眠与心血管和代谢疾病的风险指标之间的联系，如皮质醇，脂质和葡萄糖水平。本研究旨在确定多导睡眠图测量睡眠障碍（从睡眠中唤醒的频率，总睡眠时间和睡眠效率）和一些这样的指标之间的关系。第二个目的是将唤醒次数与情绪、压力、工作特征和日常生活中其他可能的预测因素联系起来。方法：24人（10名男性，14名女性;平均年龄30岁），高与低的倦怠，从瑞典IT公司招募。多导睡眠图记录的睡眠是在工作日之前在家里测量的。在随后的工作日测量血压、心率、早晨血样和唾液皮质醇样本。他们还记录了睡眠和压力的日记评级，并完成了睡眠，压力，工作条件和情绪评级的问卷调查。结果如下：以睡眠参数作为预测因子的逐步回归分析显示，觉醒次数是早晨皮质醇（血清和唾液）、心率、收缩压和舒张压、总胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇和LDL/HDL比率的最佳预测因子。工作压力/工作和休闲时间之间的界限不清是最好的预测唤醒的压力变量。结论：与睡眠限制实验相一致，睡眠片段与压力相关疾病的代谢和心血管风险指标水平升高有关。唤醒次数似乎也与工作量/压力有关。
Objective: Previous work has demonstrated a link between restricted sleep and risk indicators for cardiovascular and metabolic disease, such as levels of cortisol, lipids, and glucose. The present study sought to identify relations between polysomnographic measures of disturbed sleep (frequency of arousals from sleep, total sleep time, and sleep efficiency) and a number of such indicators. A second purpose was to relate the number of arousals to mood, stress, work characteristics, and other possible predictors in daily life. Methods: Twenty-four people (10 men, 14 women; mean age 30 years), high vs. low on burnout, were recruited from a Swedish IT company. Polysomnographically recorded sleep was measured at home before a workday. Blood pressure, heart rate, morning blood sample, and saliva samples of cortisol were measured the subsequent working day. They were also recorded for diary ratings of sleep and stress, and a questionnaire with ratings of sleep, stress, work conditions, and mood was completed. Results: A stepwise regression analysis using sleep parameters as predictors brought out number of arousals as the best predictor of morning cortisol (serum and saliva), heart rate, systolic and diastolic blood pressure, total cholesterol, high-density lipoprotein (HDL)-, low-density lipoprotein (LDL)-cholesterol, and LDL/HDL-ratio. Work stress/unclear boundaries between work and leisure time was the best predictor of arousals among the stress variables. Conclusion: Consistent with sleep restriction experiments, sleep fragmentation was associated with elevated levels of metabolic and cardiovascular risk indicators of stress-related disorders. Number of arousals also seems to be related to workload/stress.