Sexual function and neuropeptide Y levels in selected brain regions in male spontaneously hypertensive rats.
Sexual function and neuropeptide Y levels in selected brain regions in male spontaneously hypertensive rats.
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雄性自发性高血压大鼠选定脑区的性功能和神经肽 Y 水平。
DOI：
10.1152/ajpregu.1991.261.5.r1234
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kalra,SP
中科院分区：
文献类型：
--
作者：
Clark,JT;Sahu,A;Mrotek,JJ;Kalra,SP
对 8 至 20 周龄的自发性高血压大鼠 (SHR) 进行性功能检查，并与血压正常的 Wistar-Kyoto (WKY) 和 Long-Evans 大鼠 (LE) 进行比较。相对于 WKY 和 LE (135-144 mmHg)，SHR 的血压（间接评估）升高（16 周和 19 周分别为 185 +/- 2 和 195 +/- 3 mmHg）。 SHR 表现出良好的交配行为，但在前交配测试中显示出较少的勃起（少于 WKY 或 LE 所显示数量的 20%）。研究结束时（20 周龄），SHR 的体重最低，WKY 的体重中等，LE 的体重最高。 SHR 中睾丸的相对重量较大，而附属器官、垂体、肾上腺和肾脏的相对重量在各品系中是相当的，醛固酮的循环水平也是如此。 SHR 和 WKY 的睾酮循环水平高于 LE。 SHR 患者中视前核和弓状核中的神经肽 Y (NPY) 水平显着高于 WKY 或 LE 患者，而 SHR 和 WKY 患者内侧视前区以及视交叉上核、下丘脑背内侧核和下丘脑室旁核中的 NPY 水平相当，均高于 LE。杏仁核内侧核、终纹床核、正中隆起、下丘脑前核或下丘脑背内侧核没有明显的应变差异。
Sexual function was examined in spontaneously hypertensive rats (SHR) from 8 to 20 wk of age and compared with normotensive Wistar-Kyoto (WKY) and Long-Evans rats (LE). Blood pressures (evaluated indirectly) were elevated in SHR (185 +/- 2 and 195 +/- 3 mmHg at 16 and 19 wk of age, respectively) relative to WKY and LE (135-144 mmHg). SHR exhibited good copulatory behavior but displayed fewer erections (less than 20% of the number displayed by WKY or LE) in ex copula tests. At the conclusion of the study (20 wk of age), body weights were lowest in SHR, intermediate in WKY, and greatest in LE. Relative weights of testes were greater in SHR, whereas relative weights of accessory organs, pituitary and adrenal glands, and kidneys were equivalent across strains, as were circulating levels of aldosterone. Circulating levels of testosterone were higher in SHR and WKY than in LE. Neuropeptide Y (NPY) levels in the median preoptic and arcuate nuclei were significantly greater in SHR than in WKY or LE, whereas NPY levels in the medial preoptic area and the suprachiasmatic, hypothalamic dorsomedial, and hypothalamic paraventricular nuclei were equivalent in SHR and WKY, with both greater than LE. No strain differences were evident in the medial nucleus of the amygdala, the bed nucleus of the stria terminalis, the median eminence, the anterior hypothalamic nucleus, or the hypothalamic dorsomedial nucleus.