Woes with flows under pressure.
Woes with flows under pressure.
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压力下流动的困境。
DOI：
10.1093/braincomms/fcab094
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发表时间：
2021
影响因子：
4.8
通讯作者：
Iliff,JeffreyJ
中科院分区：
文献类型：
--
作者：
Jansson,DeidreJ;Iliff,JeffreyJ
通过将示踪剂引入蛛网膜下CSF隔室并测量其运动进入脑组织和从脑组织清除的动力学，最直接地评估淋巴功能。尽管在啮齿动物模型中，这通常涉及通过体内双光子显微镜对荧光CSF示踪剂进行动态成像，但鞘内注射GBCA后的动态对比增强MRI已越来越多地用于定义啮齿动物2中整个脑体积中的胶质淋巴CSF流入和间质溶质流出，最近用于人类受试者。4，5本研究建立在这项工作的基础上，使用鞘内注射GBCA后的系列MRI来表征临床IIH背景下的胶质淋巴功能。6这种情况在临床上表现为一系列的
Glymphatic function is most directly assessed by introducing a tracer into the subarachnoid CSF compartment and measuring the kinetics of its movement into and clearance from brain tissue. Although in rodent models, this has commonly involved dynamic imaging of fluorescent CSF tracer by in vivo 2-photon microscopy, 1, 3 dynamic contrastenhanced MRI following intrathecal GBCA injection has increasingly been used to define glymphatic CSF influx and interstitial solute efflux throughout the entire brain volume in rodents, 2 and more recently in human subjects. 4, 5 The present study builds upon this work, using serial MRI following intrathecal GBCA injection to characterize glymphatic function in the setting of clinical IIH. 6 This condition presents clinically as a constellation of