Structure of molecular aggregates of 1-(3-sn-phosphatidyl)-L-myo-inositol 3,4-bis(phosphate) in water.
Structure of molecular aggregates of 1-(3-sn-phosphatidyl)-L-myo-inositol 3,4-bis(phosphate) in water.
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水中 1-(3-sn-磷脂酰)-L-肌醇 3,4-二(磷酸盐) 分子聚集体的结构。
DOI：
10.1016/0005-2736(81)90578-2
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Y. Sugiura
中科院分区：
文献类型：
--
作者：
Y. Sugiura
用X射线衍射法、量热法、分析超速离心法、密度计法和粘度计研究了1-(3-sn-磷脂酰基)-L-肌醇-3，4-二磷酸/水体系在较宽的脂浓度范围内的分子结构，发现在较高的脂浓度下，脂分子形成片状相。随着含水率的增加，重复距离从60增加到120，每个脂类分子的比表面积从41.7~2增加到极限值100~2。另一方面，在很低的脂类浓度下，分子形成的不是囊泡而是胶束，其总相对分子质量为93 000。这一发现修正了流行的观点，即含有两个(或更多)碳氢链的脂类形成扩展的双层或囊泡，而单链脂类形成胶束。(Tanford，C.(1972)J.Phys.化学。76、3020-3024)。
The molecular organization of 1-(3-sn-phosphatidyl)-l-myo-inositol 3,4-bis-(phosphate)/water systems is investigated over a wide range of lipid concentrations using X-ray diffraction, calorimetry, analytical ultracentrifugation, densitometry and viscometry.At high lipid concentrations, the lipid molecules are found to form a lamellar phase. The repeat distance increases from 60 to 120 Å with increasing water content to 70 wt% and the surface area per lipid molecule increases from 41.7 Å2to a limiting value of 100 Å2.On the other hand, at very low lipid concentrations the molecules are found to form not vesicles but micelles, the total molecular weight of which takes a value of 93 000.This finding revises the prevalent view that lipids containing two (or more) hydrocarbon chains form extended bilayers or vesicles, whereas single chained lipids form micelles. (Tanford, C.(1972) J. Phys. Chem. 76, 3020–3024).