PROPERTIES AND FUNCTION OF LYSYL OXIDASE
PROPERTIES AND FUNCTION OF LYSYL OXIDASE
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DOI：
10.1165/ajrcmb/5.3.206
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发表时间：
1991-09-01
影响因子：
6.4
通讯作者：
TRACKMAN, PC
中科院分区：
文献类型：
--
作者：
KAGAN, HM;TRACKMAN, PC
赖氨酰氧化酶催化肽基赖氨酸氧化成α-氨基己二酸-δ-半醛，α-氨基己二酸-δ-半醛是稳定弹性蛋白和胶原纤维的共价交联的前体。这种酶含有铜和与邻醌一致的羰基辅因子。所提出的作用机制来自于现有的动力学和化学数据，也可以解释特定单胺和二胺对酶的基于机制的抑制。生物合成的前体和赖氨酰氧化酶的调节纤维化和恶性疾病的最新证据进行了讨论。
Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.