The term CAKUT has outlived its usefulness: the case for the prosecution.
The term CAKUT has outlived its usefulness: the case for the prosecution.
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DOI：
10.1007/s00467-022-05576-4
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发表时间：
2022-11
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影响因子：
--
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--
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CAKUT代表先天性肾脏和泌尿道异常，首字母缩略词首次出现在1998年发表的一篇综述文章中。从那时起，CAKUT已成为医学文献中遇到的熟悉术语，特别是在肾脏病学期刊中。我的理由是，CAKUT一词并不是对各种疾病的简单描述，而是一个大胆的概念包的简写，它将不同类型的解剖畸形的发生与遗传和发育生物学研究的见解联系起来。此外，血管紧张素II受体2型被视为CAKUT病理生物学中的典型分子。我认为，这个缩略语虽然在构思时看起来是一个很好的智力想法，但已经失去了它的用处。为了得出这些结论，我专注于导致CAKUT理论背后的研究观察的复杂性，然后质疑这些科学基础是否仍然稳固。此外，值得注意的是，并不是所有的临床医生都采用了首字母缩略词，我推测为什么会这样。我继续证明，有一个不相容的语义之间的CAKUT和疾病的术语最初设想。相反，我建议缩写UTM，代表尿路畸形，是一个更简单，更明确的使用。最后，我认为继续使用这个缩写是肾脏病学和泌尿学学科的一个倒退，把我们带回了两个世纪，当时所有的肾脏疾病都被简单地称为Bright病。
CAKUT stands for Congenital Anomalies of the Kidney and Urinary Tract, and the acronym first appeared in a review article published in 1998. Since then, CAKUT has become a familiar term encountered in the medical literature, especially in nephrology journals. I reason that the term CAKUT was conceived as not a simple description of various diseases, but more as shorthand for a bold conceptual package that linked the occurrence of diverse types of anatomical malformations with insights from genetic and developmental biology research. Moreover, the angiotensin II receptor type 2 was seen as a paradigmatic molecule in the pathobiology of CAKUT. I contend that the acronym, while appearing as an intellectually good idea at the time it was conceived, has outlived its usefulness. To reach these conclusions, I focus on the complex of research observations that led to the theory behind CAKUT, and then question whether these scientific foundations still stand firm. In addition, it is noted that not all clinicians have adopted the acronym, and I speculate why this is the case. I proceed to demonstrate that there is an incompatibility between the semantic meaning of CAKUT and the diseases for which the term was originally conceived. Instead, I suggest the acronym UTM, standing for Urinary Tract Malformation, is a simpler and less ambiguous one to use. Finally, I contend that the continued use of the acronym is a regressive step for the disciplines of nephrology and urology, taking us back two centuries when all kidney diseases were simply called Bright’s disease.
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影响因子：
3.7
作者：
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