X chromosome evidence for ancient human histories
X chromosome evidence for ancient human histories
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DOI：
10.1073/pnas.96.6.3320
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发表时间：
1999-03-16
影响因子：
11.1
通讯作者：
Hey, J
中科院分区：
文献类型：
--
作者：
Harris, EE;Hey, J
X连锁PDHA1（丙酮酸脱氢酶E1α亚基）基因座的不同非洲和非非洲样本揭示了两个样本组之间固定的DNA序列差异。人口细分开始的年龄似乎约为20万年前，这早于最早的现代人类化石，表明向现代人类的转变发生在细分的人口中。 PDHA1基因树的基础相对古老，估计年龄为186万年，属于上新世晚期，与早期人属物种有关。 PDHA1 显示非非洲人之间的变异非常低，但在其他方面，该数据与其他 S 连锁和常染色体单倍型数据集的报告一致。与这些其他基因一样，PDHA1 没有显示出人口扩张的证据，但与微卫星和线粒体数据相冲突。
Diverse African and non-African samples of the X-linked PDHA1 (pyruvate dehydrogenase E1 alpha subunit) locus revealed a fixed DNA sequence difference between the two sample groups. The age of onset of population subdivision appears to be about 200 thousand years ago, This predates the earliest modern human fossils, suggesting the transformation to modern humans occurred in a subdivided population. The base of the PDHA1 gene tree is relatively ancient, with an estimated age of 1.86 million years, a late Pliocene time associated with early species of Homo. PDHA1 revealed very low variation among non-Africans, but in other respects the data are consistent with reports from other S-linked and autosomal haplotype data sets. Like these other genes, but in conflict with microsatellite and mitochondrial data, PDHA1 does not show evidence of human population expansion.