PEDiDBS: The pediatric international deep brain stimulation registry project
PEDiDBS: The pediatric international deep brain stimulation registry project
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DOI：
10.1016/j.ejpn.2016.06.002
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发表时间：
2017-01-01
影响因子：
3.1
通讯作者：
Sanger, Terence D.
中科院分区：
文献类型：
--
作者：
Marks, Warren;Bailey, Laurie;Sanger, Terence D.
背景资料：交互式神经调节代表了涉及感觉器官和神经系统的各种疾病的外科治疗中不断发展的前沿。在神经科和神经外科先驱的基础上，自引入脑深部电刺激（DBS）以来，已经取得了进展。微电极记录极大地帮助我们了解运动障碍的潜在发病机制和电刺激的影响。引入图像引导系统以向特定脑区域提供靶向的、受控的神经刺激是一种新兴的植入技术，并且可能对儿科患者具有特殊的吸引力。其在其他儿科运动障碍中的潜在作用尚不明确。这一点很重要，因为大多数形式的肌张力障碍开始于儿童或青少年时期，并且许多对当前的药物治疗和其他干预措施反应不足。尽管如此，脑深部电刺激的许多方面需要澄清。结论：这只能通过一个有组织的数据共享平台来实现，这将允许提出问题并希望得到回答，最终目标是制定基于实践的循证指南，阐明DBS在儿科患者中的作用。(C)2016年欧洲儿科神经病学学会。由爱思唯尔有限公司出版。保留所有权利。
Background: Interactive neuromodulation represents the evolving frontier in surgical treatment of a variety of disorders involving the sensory organs and nervous system. Building on the advances of pioneering neurologists and neurosurgeons, progress has been made since the introduction of deep brain stimulation (DBS). Microelectrode recording has greatly aided our understanding of the underlying pathogenesis of movement disorders and the effects of electrical stimulation. The introduction of image - guided systems to provide targeted, controlled neuro-stimulation to specific brain areas is an emerging technique for implantation and may have special appeal for pediatric patients.Rationale/Aim: DBS is generally accepted as a treatment for some forms of childhood dystonia. Its potential role in other pediatric movement disorders is less well established. This is important, as most forms of dystonia begin in childhood or adolescence and many are inadequately responsive to current pharmacotherapy and other interventions. Nonetheless, many aspects of deep brain stimulation need clarification.Conclusion: This can only be accomplished through an organized platform for data sharing that will allow questions to be asked and hopefully answered, with the ultimate goal of developing evidence based practice based guidelines elucidating the role of DBS in pediatric patients. (C) 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.