Mouse models for the study of clustered protocadherins.
Mouse models for the study of clustered protocadherins.
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DOI：
10.1016/bs.ctdb.2021.12.006
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发表时间：
2022
影响因子：
--
通讯作者：
Garrett, Andrew M
中科院分区：
文献类型：
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作者：
McLeod, Cathy M;Garrett, Andrew M
自首次描述以来，成簇原钙粘蛋白（cPcdhs）因其产生不同细胞表面识别线索的潜力及其在神经系统中的广泛表达而引起了人们的兴趣。通过使用小鼠模型，我们已经了解了大量关于cPcdhs的功能，以及它们的分子多样性是如何调节的。cPcdhs是神经回路形成过程中许多过程的重要贡献者，包括神经元存活、树突和轴突分支、自我回避和靶向以及突触形成。它们的表达受表观遗传标记与涉及高阶DNA环的近端和远端元件的相互作用控制，调节转录因子结合。在这里，我们将审查各种小鼠模型针对cPcdh基因座，以及它们如何在揭示cPcdhs的调节和功能方面具有指导意义。
Since their first description, the clustered protocadherins (cPcdhs) have sparked interest for their potential to generate diverse cell-surface recognition cues and their widespread expression in the nervous system. Through the use of mouse models, we have learned a great deal about the functions served by cPcdhs, and how their molecular diversity is regulated. cPcdhs are essential contributors to a host of processes during neural circuit formation, including neuronal survival, dendritic and axonal branching, self-avoidance and targeting, and synapse formation. Their expression is controlled by the interplay of epigenetic marks with proximal and distal elements involving high order DNA looping, regulating transcription factor binding. Here, we will review various mouse models targeting the cPcdh locus and how they have been instructive in uncovering the regulation and function of the cPcdhs.