Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART
Increased microglia activation in neurologically asymptomatic HIV-infected patients receiving effective ART
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DOI：
10.1097/01.aids.0000432467.54003.f7
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发表时间：
2014-01-02
期刊：
影响因子：
3.8
通讯作者：
Winston, Alan
中科院分区：
文献类型：
--
作者：
Garvey, Lucy J.;Pavese, Nicola;Winston, Alan
Background:Neuroinflammation plays an important role in HIV-associated neurological disorders; however, its role prior to the onset of symptomatic disease is unclear. We imaged microglial activation, the hallmark of neuroinflammation, in asymptomatic HIV-infected patients on effective combination ART.Methods:Seven neurologically and cognitively asymptomatic adults with chronic HIV-infection and nine healthy volunteers were investigated with [11C]-PK11195 PET, a marker of translocator protein (TSPO) expressed by activated microglia. In the HIV-infected patients, cognitive speed, accuracy and executive function were also assessed. Between-group differences in [11C]-PK11195 binding potential were localized throughout the brain with statistical parametric mapping (SPM) and associations between levels of [11C]-PK11195 binding and cognitive performance were interrogated using linear regression modelling.Results:In HIV-infected patients, Statistical parametric mapping detected clusters of significantly increased [11C]-PK11195 binding in corpus callosum (P=0.001), anterior cingulate (P=0.001), posterior cingulate (P=0.008) and temporal (P=0.026) and frontal (P=0.038) areas. Cognitive functions were intact in the HIV group, however, a significant association between greater [11C]-PK11195 binding and poorer executive function performance was observed in the anterior cingulate (P=0.031), corpus callosum and posterior cingulate (P=0.001).Conclusion:Despite effective control of HIV infection, neuroinflammation, as evidenced by the presence of focal cortical areas of activated microglia, occurs in asymptomatic HIV-infected patients and levels correlate with poorer executive performance. Further studies are needed to establish whether detection of activated microglia in HIV-infected patients represents a marker of future neurocognitive decline.
