Reply: Antipsychotic Agents and Delirium.
Reply: Antipsychotic Agents and Delirium.
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答复：抗精神病药物和谵妄。
DOI：
10.1164/rccm.201505-1037le
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发表时间：
2015
影响因子：
24.7
通讯作者：
Gong,MichelleN
中科院分区：
文献类型：
--
作者：
Hsieh,SJean;Soto,GracielaJ;Hope,AlukoA;Ponea,Ana;Gong,MichelleN
Although longer-term use of typical and atypical antipsychotics in older patients with dementia-related psychosis has been associated with an increased risk for sudden cardiac death (2-4), short-term antipsychotic use in the intensive care unit (ICU) and in perioperative settings has been shown to be safe (5-7). Furthermore, as Dr. Song indicated, limited evidence suggests that administration of antipsychotics to critically ill patients may improve clinical outcomes (7, 8). We did not find an association between antipsychotics and in-hospital mortality in bivariate analyses, and the addition of antipsychotic use to our multivariate model did not significantly alter the associations among acute respiratory distress syndrome, ICU delirium and coma, and in-hospital mortality. Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA; www. clinicaltrials. gov, NCT 01211522), an ongoing large, multicenter, randomized placebo-controlled trial, will hopefully provide more definitive answers regarding the efficacy and safety of typical and atypical antipsychotics for the treatment of ICU delirium.■
