Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria.
Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria.
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DOI：
10.3389/fpubh.2022.834800
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发表时间：
2022
影响因子：
5.2
通讯作者：
Hou, Lifang
中科院分区：
文献类型：
--
作者：
Musa, Jonah;Kim, Kyeezu;Zheng, Yinan;Qu, Yishu;Joyce, Brian T.;Wang, Jun;Nannini, Drew R.;Gursel, Demirkan B.;Silas, Olugbenga;Abdulkareem, Fatimah B.;Imade, Godwin;Akanmu, Alani S.;Wei, Jian-Jun;Kocherginsky, Masha;Kim, Kwang-Youn A.;Wehbe, Firas;Achenbach, Chad J.;Anorlu, Rose;Simon, Melissa A.;Sagay, Atiene;Ogunsola, Folasade T.;Murphy, Robert L.;Hou, Lifang
关键词：
Invasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research has been conducted on this topic in Africa where the population is most severely affected by HIV-associated ICC. Here, we investigated the association between ICC and EAA using cervical tissues of ICC-diagnosed Nigerian women living with HIV. We included 116 cervical tissue samples from three groups of Nigerian women in this study: (1) HIV+/ICC+ (n = 39); (2) HIV+/ICC- (n = 53); and (3) HIV-/ICC + (n = 24). We utilized four DNA methylation-based EAA estimators; IEAA, EEAA, GrimAA, and PhenoAA. We compared EAA measurements across the 3 HIV/ICC groups using multiple linear regression models. We also compared EAA between 26 tumor tissues and their surrounding normal tissues using paired t-tests. We additionally performed a receiver operating characteristics (ROC) curve analysis to illustrate the area under the curve (AUC) of EAA in ICC. We found the most striking associations between HIV/ICC status and PhenoAge acceleration (PhenoAA). Among HIV-positive women, PhenoAA was on average 13.4 years higher in women with ICC compared to cancer-free women (P = 0.005). PhenoAA was 20.7 and 7.1 years higher in tumor tissues compared to surrounding normal tissues among HIV-positive women (P = 0.009) and HIV-negative women (P = 0.284), respectively. We did not find substantial differences in PhenoAA between HIV-positive and HIV-negative women with ICC. PhenoAA is associated with ICC in HIV-infected women in our study. Our findings suggest that PhenoAA may serve as a potential biomarker for further risk stratification of HIV-associated ICC in Nigeria and similar resource-constrained settings.
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DOI：
10.1093/infdis/jiv277
发表时间：
2015-11-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Horvath S;Levine AJ
通讯作者：
Levine AJ
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影响因子：
16
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通讯作者：
Zhang, Kang
DOI：
10.4137/cmo.s12017
发表时间：
2013
期刊：
Clinical Medicine Insights. Oncology
影响因子：
--
作者：
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通讯作者：
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影响因子：
5.7
作者：
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通讯作者：
Pusztai, Lajos
影响因子：
34.3
作者：
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通讯作者：
Bray, Freddie