Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy
Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy
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DOI：
10.1097/00008469-200512000-00007
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发表时间：
2005-12-01
影响因子：
2.4
通讯作者：
Loriot, MA
中科院分区：
文献类型：
--
作者：
Clavel, J;Bellec, S;Loriot, MA
代谢多态性可能会影响与母亲吸烟、咖啡或饮酒相关的儿童白血病风险。数据来自一项病例对照研究，其中包括 280 例急性白血病病例和 288 例对照。对 219 名病例和 105 名对照的代表性子集进行了血液采样。使用病例对照和仅病例分析来估计基因-环境相互作用。 CYP1A1、GSTM1、GSTP1、GSTT1和NQO1的多态性与白血病风险无关。慢 EPHX1 等位基因与儿童白血病呈负相关，而与快 EPHX1 等位基因呈反向非显着相关。母亲怀孕期间吸烟与白血病无关，但在仅病例分析中观察到与 CYP1A1*2A 变异等位基因（比值比 (OR) 2.2 [1.0-4.9]）和 GSTM1 缺失（OR 2.3 [1.2-4.4]）的相互作用。相反，在仅病例分析中，喝咖啡与 NQO1 多态性存在负相互作用（少量和大量咖啡消耗的 OR 分别为 0.6 [0.3-1.2] 和 0.4 [0.1-1.0]）。这项研究表明，母亲吸烟可能是携带 CYP1A1 或 GSTM1 基因型的儿童患白血病的危险因素，这可能会增加多环芳烃的反应性代谢产物。欧洲癌症预防杂志 14:531-540 (c) 2005 Lippincott Williams & Wilkins。
Metabolic polymorphisms may influence the risk of childhood leukaemia related to maternal tobacco, coffee or alcohol consumption. The data were extracted from a case-control study including 280 cases of acute leukaemia and 288 controls. Blood sampling was obtained for a representative subset of 219 cases and 105 controls. Gene-environment interactions were estimated using both case-control and case-only analyses. The polymorphisms of CYP1A1, GSTM1, GSTP1, GSTT1 and NQO1 were not associated with the risk of leukaemia. The slow EPHX1 allele was negatively associated with childhood leukaemia while an inverse non-significant association was observed with the fast EPHX1 allele. Maternal smoking during pregnancy was not related to leukaemia, but an interaction was observed in the case-only analysis with CYP1A1*2A variant allele (odds ratio (OR) 2.2 [1.0-4.9]) and with GSTM1 deletion (OR 2.3 [1.2-4.4]). Conversely, coffee drinking interacted negatively with NQO1 polymorphism in the case-only analysis (OR 0.6 [0.3-1.2] and 0.4 [0.1-1.0] for light and heavy coffee consumptions, respectively). This study suggests that maternal smoking may be a risk factor for leukaemia in children who carry CYP1A1 or GSTM1 genotypes, which might increase reactive metabolites of polycyclic aromatic hydrocarbons. European Journal of Cancer Prevention 14:531-540 (c) 2005 Lippincott Williams & Wilkins.