Excimer laser ablation of the cornea and lens. Experimental studies.
Excimer laser ablation of the cornea and lens. Experimental studies.
复制标题
准分子激光烧蚀角膜和晶状体。
DOI：
10.1016/s0161-6420(85)33962-3
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发表时间：
1985
期刊：
影响因子：
13.7
通讯作者：
Adler,CM
中科院分区：
文献类型：
--
作者：
Puliafito,CA;Steinert,RF;Deutsch,TF;Hillenkamp,F;Dehm,EJ;Adler,CM
脉冲紫外准分子激光已被用于产生高精度的组织消融，并且对邻近结构的热损害最小。在193 nm和248 nm准分子激光消融角膜和晶状体的对比研究中，248 nm激光消融角膜和晶状体的阈值剂量高于193 nm。在193 nm处消融角膜基质产生了最精确的切割。经透射电子显微镜检查，在激光切除的组织附近可见一小段狭窄的受损组织(0.1m~0.3μm)。248 nm辐射消融后，邻近基质中的切口边缘粗糙，损伤区更宽、更严重。对角膜基质的紫外光透过率研究表明，193 nm处的吸光度是248 nm处的10倍。准分子激光在体外有效地产生了良好控制的晶状体消融，其效果与在角膜中看到的效果平行。
The pulsed ultraviolet excimer laser has been used to produce tissue ablation with a high degree of precision and with minimal thermal damage to adjacent structures. In comparative studies of excimer laser ablation of the cornea and crystalline lens using 193 nm and 248 nm radiation, threshold fluence for corneal and lens ablation was higher at 248 nm than at 193 nm. Ablation of corneal stroma at 193 nm produced the most precise cuts. When examined by transmission electron microscopy, a narrow zone of damaged tissue (0.1 to 0.3 μm) was seen immediately adjacent to the tissue removed by the laser. Ablation with 248 nm radiation produced incisions with ragged edges and with a wider and more severe zone of damage in adjacent stroma. Ultraviolet spectral transmission studies of the corneal stroma showed that absorption is 10 times greater at 193 nm than at 248 nm. The excimer laser was effective in producing well controlled ablation of the crystalline lens in vitro, with effects parallel to those seen in the cornea.