A New Approach to Nitrones through Cascade Reaction of Nitro Compounds Enabled by Visible Light Photoredox Catalysis
A New Approach to Nitrones through Cascade Reaction of Nitro Compounds Enabled by Visible Light Photoredox Catalysis
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DOI：
10.1021/acs.orglett.5b00684
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发表时间：
2015-05-15
期刊：
影响因子：
5.2
通讯作者：
Lee, Gene-Hsiang
中科院分区：
文献类型：
--
作者：
Lin, Cheng-Wei;Hong, Bor-Cherng;Lee, Gene-Hsiang
采用可见光照射光催化工艺，将一系列硝基烷烃有效地转化为烷基硝基酮。温和、高效、环保的反应方法涉及级联途径的动态往复，包括Ru(bpy)(3)Cl-2光氧化还原催化剂和CH3CN中的DIPIBA或Hunig碱的混合物。值得注意的是，DIPIBA是硝基烷烃与醛的交叉缩合反应的最佳添加剂。x射线分析证实了相应产物的结构。
A series of nitroalkanes were efficiently transformed to alkylnitrones using a visible light irradiation photocatalytic process. The mild, efficient, and environmentally benign reaction method, involving dynamic reciprocations of cascade pathways, comprises a mixture of a Ru(bpy)(3)Cl-2 photoredox catalyst and DIPIBA or Hunig's base in CH3CN. Notably, DIPIBA was found to be the best additive for the cross condensation reaction of nitroalkanes with aldehydes. The structures of appropriate products were confirmed by X-ray analysis.