Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation.

Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation.
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DOI:
10.2337/db15-0203
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发表时间:
2015-07
期刊:
影响因子:
7.7
通讯作者:
Seale P
Seale P
中科院分区:
医学1区
文献类型:
--
作者:
Seale P

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Brown and beige adipose tissue is specialized for heat production and can be activated to reduce obesity and metabolic dysfunction in animals. Recent studies also have indicated that human brown fat activity levels correlate with leanness. This has revitalized interest in brown fat biology and has driven the discovery of many new regulators of brown fat development and function. This review summarizes recent advances in our understanding of the transcriptional mechanisms that control brown and beige fat cell development.
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