COMPLETENESS OF REGISTRATION OF CHILDHOOD LEUKEMIA NEAR NUCLEAR INSTALLATIONS AND ELSEWHERE IN THE OXFORD REGION
COMPLETENESS OF REGISTRATION OF CHILDHOOD LEUKEMIA NEAR NUCLEAR INSTALLATIONS AND ELSEWHERE IN THE OXFORD REGION
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DOI：
10.1136/bmj.299.6705.952
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发表时间：
1989-10-14
影响因子：
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通讯作者：
DOLL, R
中科院分区：
文献类型：
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作者：
DRAPER, GJ;BOWER, BD;DOLL, R
据报告，核设施周围地区的儿童白血病发病率高于其他地区。居住在核设施附近的儿童的白血病发病率通常与英格兰和威尔士或该地区的发病率进行比较。有人认为，死亡率较高反映了设施周围地区的案件登记比其他地方更完整。为了确定这是否影响报告的发病率，我们需要知道英格兰和威尔士或某个地区的公布发病率是否反映了儿童白血病的真实发病率。西伯克希尔、贝辛斯托克和北汉普郡的行政区包括或靠近位于奥尔德马斯顿的原子武器研究机构、位于伯格菲尔德的皇家奥伦斯工厂和位于哈韦尔的英国原子能管理局。Roman等人发现，在1972- 1985年期间，在设施10公里范围内的选区登记的儿童白血病病例数比国家登记率预期高40%，两个当地卫生区的其余选区的病例数仅高20%，在牛津和威塞克斯地区的其他地区的数字加起来几乎是预期的sgme。病人，方法和结果我们试图找出如何完成登记的情况下，在一个地区。我们请牛津地区各大医院的儿科顾问医生从医院和科室的记录中整理出1972年至1985年间因白血病接受治疗的儿童名单。我们将这些名称与国家儿童肿瘤登记处的名称进行了比较，后者来自所有区域癌症登记处的通知。我们排除了在皇家伯克希尔医院接受治疗的儿童的数据，该医院是距离两个设施最近的儿科肿瘤诊所，因为Roman等人之前报道过，1972年在这家医院接受治疗的所有儿童-82名牛津地区卫生局的居民在国家登记处登记，我们希望将设施附近地区的登记做法与在别处练习。阿默舍姆、海威科姆、班伯里、凯特林、米尔顿凯恩斯、北安普顿、牛津和斯托克曼德维尔等地医院的顾问提供了一份名单，从中我们确定了144名15岁以下的儿童，他们在1998年至2000年期间被诊断为白血病。
The rates reported for childhood leukaemia are higher in areas around nuclear installations than in other areas. The incidence of leukaemia in children who live near nuclear installations is usually compared with that for England and Wales or for the region. It has been suggested that the higher rates reflect more complete registration of cases in areas around installations than elsewhere. To find out whether this affects the reported incidence we need to know whether the published rates for En'gland and Wales or for one region reflect the true incidence of childhood leukaemia. The-districts of West Berkshire and of Basingstoke and North Hampshire either include or are close to the Atomic Weapons Research Establishment at Aldermaston, the Royal Ordnance Factory at Burghfield, and the UK Atomic Energy Authority's establishment at Harwell. Roman et al found that during 1972-85 the number of cases of childhood leukaemia registered in electoral wards within 10 km of the installations was 40% higher than expected from national registration rates, the number of cases in the remaining wards of the two local health districts was only 20% higher, and the number in the rest of the Oxford and Wessex regions combined was nearly the sgme as the number expected.Patients, methods, and results We attempted to find out how complete the registra-tion of cases was in one region. We asked consultant paediatricians at the main hospitals in the Oxford region to compile lists of children from hospital and department records who were treated for leukaemia in 1972-85. We compared these names with those in the National Registry of Childhood Tumours, which is derived from notifications to all regional cancer registries. We excluded data on children treated at the Royal Berkshire Hospital, which was the nearest hospital with a paediatric oncology clinic to two installations, because Roman et al previously reported that all the children treated at this hospital in 1972-82 who were residents in the Oxford Regional Health Authority were in the national registry'and we wished to compare thepractice of registration in the area near the installations with the practice elsewhere. Consultants at hospitals in Amersham, High Wycombe, Banbury, Kettering, Milton Keynes, Northampton, Oxford, and Stoke Mandeville provided lists from which we identified 144 children aged under 15 years who had had a diagnosis of leukaemia during