Sleep variability and cardiac autonomic modulation in adolescents - Penn State Child Cohort (PSCC) study.
Sleep variability and cardiac autonomic modulation in adolescents - Penn State Child Cohort (PSCC) study.
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青少年的睡眠变异性和心脏自主调节 - 宾夕法尼亚州立大学儿童队列 (PSCC) 研究。
DOI：
10.1016/j.sleep.2014.10.007
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发表时间：
2015
期刊：
影响因子：
4.8
通讯作者：
Liao,Duanping
中科院分区：
文献类型：
--
作者：
Rodríguez-Colón,SolM;He,Fan;Bixler,EdwardO;Fernandez-Mendoza,Julio;Vgontzas,AlexandrosN;Calhoun,Susan;Zheng,Zhi-Jie;Liao,Duanping
目的在以人群为基础的青少年样本中，研究客观测量的习惯性睡眠模式对心脏自主神经调节(CAM)的影响。方法采用宾夕法尼亚州立大学儿童队列研究中完成随访检查的421名青少年的数据。通过心率变异性(HR)变异性(HRV)分析39小时心电图中正常R-R间期的心率变异性(HRV)，在30分钟的基础上评估CAM。心率变异性指标包括频域变量(高频、低频和低频/高频比值)和时间域变量(SDNN、RMSSD和心率或心率)。连续七个晚上使用肌动记录仪来估计夜间睡眠持续时间和上床时间。睡眠时长和睡眠效率的7夜平均值(SD)分别代表睡眠时长、时长变异性、睡眠效率和效率变异性。对高频和低频进行对数变换，进行统计分析。结果在调整了主要混杂因素后，睡眠时间变异性和效率变异性的增加与39h内较低的心率变异性和较高的心率显著相关，并且按白天和夜间分开。例如，睡眠持续时间变异性增加1小时分别与−0.14(0.04)、−0.12(0.06)和−0.16(0.05)ms2减少有关。结论习惯性睡眠时间变异性和效率变异性与较低的HRV和较高的HR相关，提示即使在健康的青少年中，不规律的睡眠模式也会对CAM产生不利影响。
ObjectiveTo investigate the effects of objectively measured habitual sleep patterns on cardiac autonomic modulation (CAM) in a population-based sample of adolescents.MethodsWe used data from 421 adolescents who completed the follow-up examination in the Penn State Children Cohort study. CAM was assessed by heart rate (HR) variability (HRV) analysis of beat-to-beat normal R-R intervals from a 39-h electrocardiogram, on a 30-min basis. The HRV indices included frequency domain (HF, LF, and LF/HF ratio), and time domain (SDNN, RMSSD, and heart rate or HR) variables. Actigraphy was used for seven consecutive nights to estimate nightly sleep duration and time in bed. The seven-night mean (SD) of sleep duration and sleep efficiency were used to represent sleep duration, duration variability, sleep efficiency, and efficiency variability, respectively. HF and LF were log-transformed for statistical analysis. Linear mixed-effect models were used to analyze the association between sleep patterns and CAM.ResultsAfter adjusting for major confounders, increased sleep duration variability and efficiency variability were significantly associated with lower HRV and higher HR during the 39-h, as well as separated by daytime and nighttime. For instance, a 1-h increase in sleep duration variability is associated with −0.14(0.04), −0.12(0.06), and −0.16(0.05) ms2decrease in total, daytime, and nighttime HF, respectively. No associations were found between sleep duration, or sleep efficiency and HRV.ConclusionHigher habitual sleep duration variability and efficiency variability are associated with lower HRV and higher HR, suggesting that an irregular sleep pattern has an adverse impact on CAM, even in healthy adolescents.