Correlations in refractive errors between siblings in the Singapore Cohort Study of Risk factors for Myopia
Correlations in refractive errors between siblings in the Singapore Cohort Study of Risk factors for Myopia
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DOI：
10.1136/bjo.2006.107441
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发表时间：
2007-06-01
影响因子：
4.1
通讯作者：
Saw, Seang Mei
中科院分区：
文献类型：
--
作者：
Guggenheim, Jeremy A.;Pong-Wong, Ricardo;Saw, Seang Mei
背景资料：在过去的1-2代人中，东南亚部分地区近视的患病率急剧上升，这表明环境因素可能是这些人群屈光发展的特别重要的决定因素。目的：评估家庭因素的贡献（共享基因和/或共享家庭环境）对新加坡学龄儿童屈光不正和眼部组成尺寸的影响。有一个或多个兄弟姐妹的315名儿童也参加了新加坡近视风险因素队列研究（SCORM）。使用一致的临床程序，在儿童7-9岁时的基线时以及接下来3年的每年随访时，在睫状肌麻痹的情况下测量屈光不正和眼部生物特征参数。孩子们花在执行各种近距离工作相关的任务的时间是从问卷调查中获得的。结果：经年龄和性别校正后，屈光不正的同胞间相关系数为0.447（95%CI为0.314 ~ 0.564），表明家族因素占该队列变量的63%~ 100%。同胞间屈光不正1年变化的相关性同样高，为0.420（95%CI 0.282至0.543）。所有的眼部组成部分的尺寸在兄弟姐妹之间都有显著的相关性，尤其是角膜曲率和玻璃体腔深度-屈光的主要结构决定因素。兄弟姐妹从事近距离工作任务（阅读、看电视、玩电子游戏、计算）和户外活动的时间在兄弟姐妹之间也高度相关（p < 0.001）。结论：共享基因和/或共享环境是新加坡儿童屈光发育的重要因素。由于近距离工作所花费的时间在兄弟姐妹之间是高度相关的，流行病学研究将受益于父母和远亲的屈光不正的精确、定量测量，以便开始分离遗传和环境变异源。
Background: The prevalence of myopia in parts of South East Asia has risen dramatically over the past 1-2 generations, suggesting that environmental factors may be particularly important determinants of refractive development in these populations.Aim: To assess the contribution of familial factors (shared genes and/or shared family environment) to refractive error and ocular component dimensions of school-aged children in Singapore.Methods: Data were available for 315 children who had one or more siblings also participating in the Singapore Cohort Study of the Risk factors for Myopia (SCORM). Refractive error and ocular biometric parameters were measured under cycloplegia at baseline when children were 7-9 years, and at yearly follow-up sessions for the next 3 years, using consistent clinical procedures. The time children spent performing a variety of nearwork-related tasks was obtained from questionnaires. Familial influences were assessed by calculating between-sibling correlations.Results: After adjusting for age and sex, the between-sibling correlation in refractive error was 0.447 (95% CI 0.314 to 0.564), suggesting that familial factors account for 63-100% of the variation in the cohort. The between-sibling correlation for 1-year change in refractive error was similarly high, at 0.420 (95% CI 0.282 to 0.543). All ocular component dimensions were correlated significantly between siblings, especially for corneal curvature and vitreous chamber depth-the major structural determinants of refraction. The amount of time siblings spent engaged in nearwork tasks (reading, watching TV, playing video games, computing) and in outdoor activities was also highly correlated between siblings (p < 0.001).Conclusion: Shared genes and/or shared environment are important factors in the refractive development of children in Singapore. Because the time spent in nearwork tasks is highly correlated between siblings, epidemiological studies will benefit from precise, quantitative measures of refractive error in parents and more distant relatives in order to begin to dissociate genetic and environmental sources of variation.