The response of a transplantable tumor to fractionated irradiation. 1. X rays and the hypoxic cell radiosensitizer Ro-07-0582.
The response of a transplantable tumor to fractionated irradiation. 1. X rays and the hypoxic cell radiosensitizer Ro-07-0582.
复制标题
可移植肿瘤对分段照射的反应。
DOI：
10.2307/3574356
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发表时间：
1976
影响因子：
3.4
通讯作者：
S. R. Harris
中科院分区：
文献类型：
--
作者：
J. Denekamp;S. R. Harris
CBA小鼠中可移植乳腺癌对单次剂量和两个或五个部分的X射线的反应，使用和不使用缺氧细胞增敏剂Ro-07-0582，已经使用肿瘤再生长延迟作为反应的测量来测试。在仅用x射线治疗的肿瘤中，亚致死损伤的修复过程和分次照射之间的复氧过程似乎相互抵消，因此当使用分次照射时，不需要额外的剂量来达到特定的损伤水平。然而，当在每次放射剂量前不久给予Ro-07-0582时，肿瘤细胞的放射敏感性变得更加均匀，因此可以在没有缺氧和复氧并发症的情况下测量它们的修复能力。在该肿瘤中测量的修复能力约为在皮肤中观察到的修复能力的50- 70%。肿瘤对不同治疗的反应与小鼠皮肤的反应有关，作为正常组织的一个例子。单独使用x射线，如果剂量分次，则可以在标准皮肤反应水平下实现更多的肿瘤延迟，这可能是由于肿瘤修复能力和再氧化的差异。当Ro-07-0582以0.67 mg/g体重存在时，恒定skinmore反应的肿瘤延迟进一步增加。在特定的肿瘤反应水平下，单次剂量的“X射线剂量增强比”为1.7，两次剂量的“X射线剂量增强比”为1.6，五次剂量的“X射线剂量增强比”为1.2。«少
The response of transplantable mammary carcinoma in CBA mice to single doses and two or five fractions of x rays, with and without the hypoxic cell sensitizer Ro-07-0582, has been tested using delay of tumor regrowth as the measure of response. In the tumors treated with x rays alone the processes of repair of sublethal injury, and reoxygenation between fractions, appeared to counteract each other so that no extra dose was needed to achieve a particular level of damage when fractionated irradiation was used. When Ro-07-0582 was administered shortly before each radiation dose, however, the tumor cells were made more uniformly radiosensitive, so that without the complication of hypoxia and reoxygenation their repair capacity could be measured. The repair capacity measured in this tumor was approximately 50-70 percent of that observed in skin. The response of the tumor to different treatments has been expressed in relation to the response of mouse skin, as an example of normal tissue. With x rays alone, more tumor delay could be achieved for a standard level of skin reaction if the dose were fractionated, due presumably to the difference in repair capacities and reoxygenation in the tumor. The tumor delay for a constant skinmore » reaction was further increased when Ro-07-0582 was present at 0.67 mg/g body weight. ''X-ray dose enhancement ratios'' of 1.7 for single doses, 1.6 for two fractions, and 1.2 for five fractions were measured at a particular level of tumor response.« less