Retinal Response to Light in Young Nonaffected Offspring at High Genetic Risk of Neuropsychiatric Brain Disorders
Retinal Response to Light in Young Nonaffected Offspring at High Genetic Risk of Neuropsychiatric Brain Disorders
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DOI：
10.1016/j.biopsych.2009.08.016
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发表时间：
2010-02-01
影响因子：
10.6
通讯作者：
Maziade, Michel
中科院分区：
文献类型：
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作者：
Hebert, Marc;Gagne, Anne-Marie;Maziade, Michel
背景：在精神分裂症（SZ）和双相情感障碍（BD）等神经精神性脑部疾病中，长期药物治疗的偏差效应和一旦安装后疾病的毒性作用对有效生物标志物的识别构成了障碍。这些生物标志物可能存在于视网膜功能水平，在患有神经精神疾病的成年人中已经报道了该异常。在这里，我们报告了这些疾病的高遗传风险 (HR) 的年轻未受影响和未接受药物治疗的后代中的特定视网膜电图 (ERG) 异常。方法：对 29 名父母之一受 DSM-IV SZ 或 BID 影响的 HR 后代（平均年龄：20.8 岁，SD 4.4）和 29 名健康对照受试者（平均年龄：20.6 岁，SD 4.2）进行视网膜电图检查。 HR 的父母来自受 SZ 或 BD 影响的多代家庭。结果：Rod ERG（HR 中 V-max 处的 b 波振幅显着低于对照受试者（p < .0001；效应大小为 -1.47），而锥体 ERG V-max 没有差异（p = .27）。未观察到性别、年龄和测试季节的影响。视网膜反应异常（杆 V-max b 波）振幅）的观察与父母的诊断无关（SZ；p = .007，效应大小为 -1.09；BID：p < .0001，效应大小为 -1.88），并且在年轻和年长 HR 中均存在（效应大小分别为 -1.6 和 -1.8）。结论：发病年龄之前的视杆细胞视网膜反应异常可能代表一种早期且特定的风险生物标志物，对于进一步遗传和预防具有意义研究。
Background: In neuropsychiatric brain disorders, such as schizophrenia (SZ) and bipolar disorder (BD), the biased effect of chronic drug therapy and the toxic effect of illness once installed constitute obstacles to the identification of valid biomarkers. Such biomarkers could lie at the level of retinal function where anomalies have already been reported in adults suffering from neuropsychiatric disorders. Here, we report a specific electroretinographic (ERG) anomaly in young nonaffected and nonmedicated offspring at high genetic risk (HR) of these disorders.Methods: Electroretinography was performed in 29 HR offspring having one parent affected by DSM-IV SZ or BID (mean age: 20.8 years, SD 4.4) and 29 healthy control subjects (mean age: 20.6 years, SD 4.2). The HRs' parents descended from multigenerational families affected by SZ or BD.Results: Rod ERG (b-wave amplitude at V-max in HRs was significantly lower than control subjects (p < .0001; effect size of -1.47), whereas the cone ERG V-max showed no difference (p = .27). No effects of gender, age, and seasons of testing were observed. The anomaly in retinal response (rod V-max b-wave amplitude) was observed independently of parents' diagnosis (SZ; p = .007, effect size of -1.09; BID: p < .0001, effect size of -1.88) and was present in both the younger and older HRs (effect size of -1.6 and -1.8, respectively).Conclusions: A rod retinal response anomaly before the age of the disease incidence may represent an early and specific biomarker of risk with meaning for further genetic and prevention research.