Bombesin increases fetal lung growth and maturation in utero and in organ culture.
Bombesin increases fetal lung growth and maturation in utero and in organ culture.
复制标题
铃蟾肽可促进胎儿肺在子宫内和器官培养中的生长和成熟。
DOI：
10.1165/ajrcmb/3.3.199
复制
发表时间：
1990
影响因子：
6.4
通讯作者：
Torday,JS
中科院分区：
文献类型：
--
作者：
Sunday,ME;Hua,J;Dai,HB;Nusrat,A;Torday,JS
胃泌素释放肽（GRP），哺乳动物的14-氨基酸肽的27-氨基酸同源物。蛙皮素是第一种定位于肺神经内分泌细胞（PNEC）的肽激素，并且在人胎儿肺中以特别高的水平存在（1）。正因为如此，人们开始猜测GRP（哺乳动物蛙皮素）可能在正常的肺发育中发挥作用。GRP或由驻留PNEC合成和分泌的任何激素（2）均未被证明在正常肺生长或分化（其共同构成肺”发育”）中起作用。GRP和蛙皮素都包括一个高度保守的10个氨基酸的羧基末端部分，它是抗体识别和结合所必需的
Gastrin-releasing peptide (GRP), the 27-amino acid mammalian homologue of the 14-amino acid amphibian peptide. bombesin, was the first peptide hormone localized to pulmonary neuroendocrine cells (PNECs), and is present at especially high levels in human fetal lung (1). Because of this, speculation began that GRP (mammalian bombesin) might play a role in normal lung development. Neither GRP nor any of the hormones synthesized and secreted by resident PNECs (2) have been demonstrated to have a role in normal lung growth or differentiation (which together comprise lung" development"). Both GRP and bombesin include a highly conserved 10-amino acid carboxy-terminal portion that is required for recognition by antibodies as well as for binding