Eighteen month study of continuous intraduodenal levodopa infusion in patients with advanced Parkinson's disease: Impact on control of fluctuations and quality of life
Eighteen month study of continuous intraduodenal levodopa infusion in patients with advanced Parkinson's disease: Impact on control of fluctuations and quality of life
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DOI：
10.1016/j.parkreldis.2009.07.015
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发表时间：
2010-03-01
影响因子：
4.1
通讯作者：
Campo, R.
中科院分区：
文献类型：
--
作者：
Puente, V.;De Fabregues, O.;Campo, R.
对9例晚期帕金森病患者连续十二指肠内左旋多巴输注（CIDLI）治疗18个月后的症状控制、每日“治疗”时间和生活质量（QoL）进行了评估。患者具有严重的运动波动和运动障碍，并且先前接受过口服左旋多巴和多巴胺激动剂的治疗。在统一帕金森病评定量表和QoL（帕金森病QoL问卷）上，患者的症状有显著改善。Schwab & England日常生活能力量表，p < 0 05）平均（+/- SD）每日“开”时间从6 1 1 9增加到12. 0 +/- 34 h（p < 0 05）APD的QoL改善与CIDLI相关的症状控制改善和每日“开”时间增加相关（C）2009由Elsevier Ltd出版
Symptom control, daily "on" time, and quality of life (QoL) of nine patients with Advanced Parkinson's Disease was assessed following 18-months treatment with Continuous Intraduodenal Levodopa Infusion (CIDLI). Patients had severe motor fluctuations and dyskinesias and had previously received treatment with oral levodopa and dopamine agonists There were significant improvements in patients' symptoms on the Unified Parkinson's Disease Rating Scale, and QoL (Parkinson's Disease QoL Questionnaire. Schwab & England Capacity for Daily Living Scale, p < 0 05) Mean (+/- SD) daily "on" time increased from 6 1 1 9 to 12.0 +/- 34 h (p < 0 05) Improved QoL in APD was associated with CIDLI-related improvements m symptom control and increase in daily "on" time (C) 2009 Published by Elsevier Ltd