Role of extracellular matrix proteoglycans in immune cell recruitment.
Role of extracellular matrix proteoglycans in immune cell recruitment.
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DOI：
10.1111/iep.12428
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发表时间：
2022-04
影响因子：
3
通讯作者：
Dyer DP
中科院分区：
文献类型：
--
作者：
Gray AL;Pun N;Ridley AJL;Dyer DP
白细胞募集是免疫反应的关键组成部分，对我们对抗感染的能力至关重要。巧合的是，白细胞募集也是炎症性疾病如类风湿性关节炎、动脉粥样硬化和癌症的核心组成部分。细胞外基质，特别是蛋白多糖在这一过程中的作用在很大程度上被忽视了。蛋白聚糖由连接有糖胺聚糖糖侧链的蛋白质核心组成。蛋白聚糖已显示结合和调节许多蛋白质（例如趋化因子）的功能，并且还在局部组织环境/生态位中发挥关键的结构作用。虽然它们与白细胞募集和炎性疾病有关，但其机制功能尚未完全了解，排除了治疗靶向。这篇综述总结了目前已知的蛋白多糖在白细胞募集的不同阶段的作用，并提出了一些需要更多研究的领域。更好地了解蛋白聚糖在炎症性疾病中的机制作用将为下一代治疗方法的开发提供信息。
Leucocyte recruitment is a critical component of the immune response and is central to our ability to fight infection. Paradoxically, leucocyte recruitment is also a central component of inflammatory‐based diseases such as rheumatoid arthritis, atherosclerosis and cancer. The role of the extracellular matrix, in particular proteoglycans, in this process has been largely overlooked. Proteoglycans consist of protein cores with glycosaminoglycan sugar side chains attached. Proteoglycans have been shown to bind and regulate the function of a number of proteins, for example chemokines, and also play a key structural role in the local tissue environment/niche. Whilst they have been implicated in leucocyte recruitment and inflammatory disease, their mechanistic function has yet to be fully understood, precluding therapeutic targeting. This review summarizes what is currently known about the role of proteoglycans in the different stages of leucocyte recruitment and proposes a number of areas where more research is needed. A better understanding of the mechanistic role of proteoglycans during inflammatory disease will inform the development of next‐generation therapeutics.
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影响因子：
3.9
作者：
Campo, Giuseppe M.;Avenoso, Angela;Calatroni, Alberto
通讯作者：
Calatroni, Alberto
影响因子：
7.8
作者：
Giuffre, L;Cordey, AS;Monai, N;Tardy, Y;Schapira, M;Spertini, O
通讯作者：
Spertini, O
DOI：
10.1369/0022155420977971
发表时间：
2021-03
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
--
作者：
Handel TM;Dyer DP
通讯作者：
Dyer DP
影响因子：
48
作者：
Chen, Yen-Hsi;Narimatsu, Yoshiki;Yang, Zhang
通讯作者：
Yang, Zhang
影响因子：
4.4
作者：
Campanella, Gabriele S. V.;Grimm, Jan;Luster, Andrew D.
通讯作者：
Luster, Andrew D.