Pulmonary function changes after radiotherapy in non-small-cell lung cancer patients with long-term disease-free survival
Pulmonary function changes after radiotherapy in non-small-cell lung cancer patients with long-term disease-free survival
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DOI：
10.1016/j.ijrobp.2004.11.029
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发表时间：
2005-07-01
影响因子：
7
通讯作者：
Lebesque, JV
中科院分区：
文献类型：
--
作者：
Borst, GR;De Jaeger, K;Lebesque, JV
目的：评价长期无病生存期非小细胞肺癌高剂量放疗（RT）后肺功能的变化。方法与材料：对34例不能手术的非小细胞肺癌患者在放疗前、随访3个月和18个月时进行肺功能测定。其中13例患者在术后36个月进行肺功能试验（PFT）。肺功能参数（1 s内用力呼气量[FEV1]、弥散量[T-lcoc]、用力肺活量和肺泡容积）以正常值的百分比表示。变化以相对于rt前值表示。我们评估了慢性阻塞性肺疾病、放射性肺炎、平均肺剂量和放疗前PFT结果对肺功能变化的影响。结果：在3、18和36个月时，观察到T-lcoc（分别为9.5%、14.6%和22.0%）和肺泡体积（分别为5.8%、6.6%和15.8%）显著下降。第18个月和第36个月时FEV1下降显著（分别为8.8%和13.4%）。没有观察到任何参数的恢复。慢性阻塞性肺疾病是PFT大幅度下降的重要危险因素。FEV1和T1.0。减少依赖于平均肺剂量。结论：放疗后3个月肺功能明显下降。放疗后18个月和36个月肺功能未见恢复。肺功能下降依赖于平均肺剂量，慢性阻塞性肺疾病患者肺功能下降更大。(c) 2005爱思唯尔公司
Purpose: To evaluate the changes in pulmonary function after high-dose radiotherapy (RT) for non-small-cell lung cancer in patients with a long-term disease-free survival.Methods and Materials: Pulmonary function was measured in 34 patients with inoperable non-small-cell lung cancer before RT and at 3 and 18 months of follow-up. Thirteen of these patients had a pulmonary function test (PFT) 36 months after RT. The pulmonary function parameters (forced expiratory volume in 1 s [FEV1], diffusion capacity [T-lcoc], forced vital capacity, and alveolar volume) were expressed as a percentage of normal values. Changes were expressed as relative to the pre-RT value. We evaluated the impact of chronic obstructive pulmonary disease, radiation pneumonitis, mean lung dose, and PFT results before RT on the changes in pulmonary function.Results: At 3, 18, and 36 months, a significant decrease was observed for the T-lcoc (9.5%, 14.6%, and 22.0%, respectively) and the alveolar volume (5.8%, 6.6%, and 15.8%, respectively). The decrease in FEV1 was significant at 18 and 36 months (8.8% and 13.4%, respectively). No recovery of any of the parameters was observed. Chronic obstructive pulmonary disease was an important risk factor for larger PFT decreases. FEV1 and T1.0. decreases were dependent on the mean lung dose.Conclusion: A significant decrease in pulmonary function was observed 3 months after RT. No recovery in pulmonary function was seen at 18 and 36 months after RT. The decrease in pulmonary function was dependent on the mean lung dose, and patients with chronic obstructive pulmonary disease had larger reductions in the PFTs. (c) 2005 Elsevier Inc.