Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice.
Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice.
复制标题
DOI：
10.1523/jneurosci.2820-08.2008
复制
发表时间：
2008-10-29
期刊：
影响因子：
--
通讯作者：
Powell EM
中科院分区：
文献类型：
--
作者：
Bissonette GB;Martins GJ;Franz TM;Harper ES;Schoenbaum G;Powell EM
许多神经精神疾病与前额叶功能障碍相关的认知僵硬有关。例如，精神分裂症和帕金森病与威斯康星卡片分类测试的表现缺陷有关，该测试评估注意力集中转移。虽然这些疾病的遗传基础可以在小鼠中复制，但很少有模型可以测试功能后果。在这里，我们证明了威斯康星卡片分类测试的类似物，在狨猴中开发，最近适用于大鼠，是小鼠前额叶功能的行为模型。系统分析表明，小鼠注意力集的形成取决于问题集的数量。我们发现，与大鼠和灵长类动物一样，小鼠也表现出情感集和注意力集，而这些功能分别被眶额和内侧前额皮质区的神经毒性损伤所破坏。这些数据与对大鼠的研究相同，与在狨猴的类似任务中前额叶受损后报告的缺陷相似。这些结果为评估小鼠前额叶功能提供了行为模型。
Many neuropsychiatric diseases are associated with cognitive rigidity linked to prefrontal dysfunction. For example, schizophrenia and Parkinson’s disease are associated with performance deficits on the Wisconsin Card Sorting Test, which evaluates attentional set-shifting. While the genetic underpinnings of these disorders can be reproduced in mice, there are few models for testing the functional consequences. Here we demonstrate that an analog of the Wisconsin Card Sorting Test, developed in marmosets and recently adapted to rats, is a behavioral model of prefrontal function in mice. Systematic analysis demonstrated that formation of the attentional set in mice is dependent upon the number of problem sets. We found that mice, like rats and primates, exhibit both affective and attentional sets, and these functions are disrupted by neurotoxic damage to orbitofrontal and medial prefrontal cortical areas, respectively. These data are identical to studies in rats and similar to the deficits reported after prefrontal damage in a comparable task in marmosets. These results provide a behavioral model to assess prefrontal function in mice.