THE SYNTAXIN FAMILY OF VESICULAR TRANSPORT RECEPTORS
THE SYNTAXIN FAMILY OF VESICULAR TRANSPORT RECEPTORS
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DOI：
10.1016/0092-8674(93)90466-4
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发表时间：
1993-09-10
期刊：
影响因子：
64.5
通讯作者：
SCHELLER, RH
中科院分区：
文献类型：
--
作者：
BENNETT, MK;GARCIAARRARAS, JE;SCHELLER, RH
突触素A和B是神经系统特有的蛋白质，与突触小泡与突触前质膜的对接有关。已从大鼠中鉴定出一个与合成素相关的蛋白家族，其氨基酸同源性为23%-84%。六种合成素中的每一种都以一个羧基末端疏水结构域终止，该结构域将蛋白质锚定在细胞膜的细胞质表面。这些合成素在组织中分布广泛，当在COS细胞中表达时，针对不同的亚细胞间隔。显微注射研究表明，神经系统特异的合成素1A对于神经内分泌PC12细胞的钙调节分泌是重要的。这些结果表明，合成素是细胞内转运囊泡的受体家族，每个靶膜可能由合成素家族中的一个特定成员识别。
Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. A family of syntaxin-related proteins from rat has been identified that shares 23%-84% amino acid identity. Each of the six syntaxins terminate with a carboxy-terminal hydrophobic domain that anchors the protein on the cytoplasmic surface of cellular membranes. The syntaxins display a broad tissue distribution and, when expressed in COS cells, are targeted to different subcellular compartments. Microinjection studies suggest that the nervous system-specific syntaxin 1A is important for calcium-regulated secretion from neuroendocrine PC12 cells. These results indicate that the syntaxins are a family of receptors for intracellular transport vesicles and that each target membrane may be identified by a specific member of the syntaxin family.