Investigating the perceived timing of sensory events triggering actions in patients with Parkinson's disease and the effects of dopaminergic therapy
Investigating the perceived timing of sensory events triggering actions in patients with Parkinson's disease and the effects of dopaminergic therapy
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研究帕金森病患者感知事件触发行为的时间以及多巴胺能治疗的效果
DOI：
10.1016/j.cortex.2019.02.009
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发表时间：
2019
期刊：
影响因子：
3.6
通讯作者：
MacDonald Penny A.
中科院分区：
文献类型：
--
作者：
Yabe Yoshiko;Goodale Melvyn A.;MacDonald Penny A.
很少有研究调查帕金森病 (PD)、年龄增长或外源性多巴胺治疗是否会影响对过去事件的感知时间。在这里，我们展示了帕金森病患者的感觉事件相对于行动决策的“时间排斥”现象。在这些患者中，感觉事件触发动作的时间被认为比实际发生的时间更早。换句话说，事件的发生时间似乎从动作的执行时间上被推迟了。这一发现与我们在此处和其他地方观察到的“时间绑定”形成鲜明对比（Yabe et al., 2017; Yabe & Goodale, 2015），在年轻健康参与者中，触发行动的感官事件的感知开始通常会延迟，就好像它被及时拉向行动一样。在老年患者中，感觉事件既不排斥也不被拉向行动决策事件。外源性多巴胺减轻了帕金森病患者的时间排斥，并使健康老年对照的时间结合正常化。相比之下，多巴胺能疗法使健康年轻参与者的颞结合恶化。我们讨论了这种发现模式，将时间结合过程与多巴胺能和纹状体机制联系起来。
Few studies have investigated if Parkinson's disease (PD), advancing age, or exogenous dopamine therapy affect the perceived timing of past events. Here we show a phenomenon of ‘temporal repulsion’ of a sensory event relative to an action decision in patients with PD. In these patients, the timing of a sensory event triggering an action was perceived to have occurred earlier in time than it really did. In other words, the event appeared to be pushed away in time from the performance of the action. This finding stands in sharp contrast to the ‘temporal binding’ we have observed here and elsewhere (Yabe et al., 2017; Yabe & Goodale, 2015) in young healthy participants for whom the perceived onset of a sensory event triggering an action is typically delayed, as if it were pulled towards the action in time. In elderly patients, sensory events were neither repulsed nor pulled toward the action decision event. Exogenous dopamine alleviated the temporal repulsion in PD patients and normalized the temporal binding in healthy elderly controls. In contrast, dopaminergic therapy worsened temporal binding in healthy young participants. We discuss this pattern of findings, relating temporal binding processes to dopaminergic and striatal mechanisms.