Integrins and the Extracellular Matrix: Key Mediators of Development and Regeneration of the Sensory Nervous System
Integrins and the Extracellular Matrix: Key Mediators of Development and Regeneration of the Sensory Nervous System
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DOI：
10.1002/dneu.20950
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发表时间：
2011-11-01
影响因子：
3
通讯作者：
Gardiner, Natalie J.
中科院分区：
文献类型：
--
作者：
Gardiner, Natalie J.
体感觉神经系统负责将大量的感觉信息从外周的特殊受体传递到中枢神经系统。感觉传入可能在以下几个部位受到损伤：周围神经；背根；或者脊髓的背柱；再生的成功与否取决于受伤的部位。与中央神经分支相比，周围神经分支损伤后的再生相对成功。这在很大程度上归因于神经营养因子和雪旺细胞基底膜的存在，这种基底膜富含可促进周围神经轴突再生的允许细胞外基质（ECM）成分。外基质环境和/或神经元整合素的调节可增强外周或中枢神经损伤或疾病后感觉神经元的再生潜能。本文综述了整合素和ECM分子（特别是生长支持配体、层粘连蛋白和纤维连接蛋白）以及生长抑制硫酸软骨素蛋白聚糖（CSPGs）在物理损伤或神经病变后感觉神经元发育和再生过程中的相互作用。(C) 2011 Wiley期刊公司中国生物医学工程学报（英文版），2011
The somatosensory nervous system is responsible for the transmission of a multitude of sensory information from specialized receptors in the periphery to the central nervous system. Sensory afferents can potentially be damaged at several sites: in the peripheral nerve; the dorsal root; or the dorsal columns of the spinal cord; and the success of regeneration depends on the site of injury. The regeneration of peripheral nerve branches following injury is relatively successful compared to central branches. This is largely attributed to the presence of neurotrophic factors and a Schwann cell basement membrane rich in permissive extracellular matrix (ECM) components which promote axonal regeneration in the peripheral nerve. Modulation of the ECM environment and/or neuronal integrins may enhance regenerative potential of sensory neurons following peripheral or central nerve injury or disease. This review describes the interactions between integrins and ECM molecules (particularly the growth supportive ligands, laminin, and fibronectin; and the growth inhibitory chondroitin sulfate proteoglycans (CSPGs)) during development and regeneration of sensory neurons following physical injury or neuropathy. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1054-1072, 2011