Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective
Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective
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DOI：
10.1016/j.schres.2019.10.048
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发表时间：
2020-03-01
影响因子：
4.5
通讯作者：
Walters, James T. R.
中科院分区：
文献类型：
--
作者：
Dennison, Charlotte A.;Legge, Sophie E.;Walters, James T. R.
全基因组关联研究（GWAS）已被证明是精神分裂症基因发现的一种强有力的方法;他们的发现不仅对我们理解这种疾病的遗传结构具有重要意义，而且对通过改进分类和靶向干预来实现个性化医疗的潜在应用具有重要意义。本文就GWAS在精神分裂症中的功能注释方法、多基因风险评分等方面的研究现状进行综述，并展望未来的研究方向和挑战。我们考虑了东亚人群的最新发现和跨血统分析的进展，以及从精神疾病研究中获得的见解。(C)2019年爱思唯尔出版
Genome-wide association studies (GWAS) have proved to be a powerful approach for gene discovery in schizophrenia; their findings have important implications not just for our understanding of the genetic architecture of the disorder, but for the potential applications of personalised medicine through improved classification and targeted interventions. In this article we review the current status of the GWAS literature in schizophrenia including functional annotation methods and polygenic risk scoring, as well as the directions and challenges of future research. We consider recent findings in East Asian populations and the advancements from trans-ancestry analysis, as well as the insights gained from research looking across psychiatric disorders. (C) 2019 Published by Elsevier B.V.