Characteristics of Emergency Medicine Specimen Bank Participants Compared to the Overall Emergency Department Population.
Characteristics of Emergency Medicine Specimen Bank Participants Compared to the Overall Emergency Department Population.
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DOI：
10.5811/westjem.2022.11.57981
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发表时间：
2023-02-25
期刊：
影响因子：
--
通讯作者：
Monte AA
中科院分区：
文献类型：
--
作者：
Vest A;Sonn B;Puls R;Arnold C;Devney Z;Ahmed A;Pallisard O;Monte AA
生物储存库在人口统计学和入组患者的临床投诉方面缺乏多样性。急诊医学标本库（EMSB）旨在招募不同的患者队列，用于急性护理条件下的发现研究。本研究的目的是确定EMSB参与者与急诊科（艾德）总体人群之间的人口统计学和临床投诉差异。这是对EMSB和科罗拉多大学安舒茨医学中心（UCHealth AMC）艾德人群的整个UCHealth参与者在三个时期的回顾性分析：围EMSB;后EMSB;和COVID-19。我们将同意接受EMSB的患者与整个艾德人群进行比较，以确定年龄、性别、种族、人种、临床投诉和疾病严重程度的差异。我们使用卡方检验比较分类变量和Elixhauser合并症指数，以确定各组之间疾病严重程度的差异。在2018年2月5日至2022年1月29日期间，EMSB有141，670次同意接触，代表40，740名独特的患者和超过13，000份血液样本。在同一时间，艾德在387,590次就诊中看到了大约188,402名独特的患者。与总体艾德人群相比，以下人群的EMSB参与率显著更高：18-59岁患者（80.3% vs 77.7%）;白色患者（52.3% vs 47.8%）和女性（54.8% vs 51.1%）。≥70岁患者、西班牙裔患者、亚裔患者和男性的EMSB参与率较低。EMSB人群的平均合并症评分较高。在科罗拉多出现首例COVID-19病例后的六个月里，患者同意率和样本采集率都有所上升。在COVID-19研究期间，同意的几率为1.32（95% CI 1.26-1.39），样本采集的几率为2.19（95% CI 2.0-2.41）。EMSB代表了大多数人口统计学和临床投诉的总体艾德人群。
Biorepositories lack diversity both demographically and with regard to the clinical complaints of patients enrolled. The Emergency Medicine Specimen Bank (EMSB) seeks to enroll a diverse cohort of patients for discovery research in acute care conditions. Our objective in this study was to determine the differences in demographics and clinical complaints between participants in the EMSB and the overall emergency department (ED) population. This was a retrospective analysis of participants of the EMSB and the entire UCHealth at University of Colorado Anschutz Medical Center (UCHealth AMC) ED population across three periods: peri-EMSB; post-EMSB; and COVID-19. We compared patients consented to the EMSB to the entire ED population to determine differences in age, gender, ethnicity, race, clinical complaints, and severity of illness. We used chi-square tests to compare categorical variables and the Elixhauser Comorbidity Index to determine differences in the severity of illness between the groups. Between February 5, 2018–January 29, 2022, there were 141,670 consented encounters in the EMSB, representing 40,740 unique patients and over 13,000 blood samples collected. In that same time, the ED saw approximately 188,402 unique patients for 387,590 encounters. The EMSB had significantly higher rates of participation from the following: patients 18–59 years old (80.3% vs 77.7%); White patients (52.3% vs 47.8%), and women (54.8% vs 51.1%) compared to the overall ED population. The EMSB had lower rates of participation from patients ≥70 years, Hispanic patients, Asian patients, and men. The EMSB population had higher mean comorbidity scores. During the six months after Colorado’s first COVID-19 case, the rate of consented patients and samples collected increased. The odds of consent during the COVID-19 study period were 1.32 (95% CI 1.26–1.39), and the odds of sample capture were 2.19 (95% CI 2.0–2.41). The EMSB is representative of the overall ED population for most demographics and clinical complaints.
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影响因子：
6.7
作者：
Gonsalves, Stephen G.;Dirksen, Robert T.;Biesecker, Leslie G.
通讯作者：
Biesecker, Leslie G.
影响因子：
1.5
作者：
Hooker, Edmond A.;Mallow, Peter J.;Oglesby, Michelle M.
通讯作者：
Oglesby, Michelle M.
影响因子：
2.3
作者：
McCarty, Catherine A;Wilke, Russell A;Caldwell, Michael D
通讯作者：
Caldwell, Michael D
DOI：
10.1038/gim.2015.187
发表时间：
2016-09
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Carey DJ;Fetterolf SN;Davis FD;Faucett WA;Kirchner HL;Mirshahi U;Murray MF;Smelser DT;Gerhard GS;Ledbetter DH
通讯作者：
Ledbetter DH
DOI：
10.1038/s43856-021-00042-y
发表时间：
2021
期刊：
Communications medicine
影响因子：
--
作者：
Konigsberg IR;Barnes B;Campbell M;Davidson E;Zhen Y;Pallisard O;Boorgula MP;Cox C;Nandy D;Seal S;Crooks K;Sticca E;Harrison GF;Hopkinson A;Vest A;Arnold CG;Kahn MG;Kao DP;Peterson BR;Wicks SJ;Ghosh D;Horvath S;Zhou W;Mathias RA;Norman PJ;Porecha R;Yang IV;Gignoux CR;Monte AA;Taye A;Barnes KC
通讯作者：
Barnes KC