Building a clinically relevant cognitive task: Case study of the AX paradigm
Building a clinically relevant cognitive task: Case study of the AX paradigm
复制标题
DOI：
10.1093/schbul/sbn038
复制
发表时间：
2008-07-01
影响因子：
6.6
通讯作者：
MacDonald, Angus W., III
中科院分区：
文献类型：
--
作者：
MacDonald, Angus W., III
为基础认知神经科学开发的任务通常不适合实验精神病理学。开发AX连续表现任务的期望变体来测试有关精神分裂症背景处理的理论，用于说明一个研究项目是如何做到这一点的。提出了四个设计原则：任务应（1）在已有文献中有基础，因此尽可能接近已有任务;（2）简单，通常通过对任务进行简化以评估兴趣函数来实现;（3）探索兴趣机制，并有选择地操纵该机制的条件;（4）有潜力区分兴趣机制上的特定缺陷和一般性损伤。来自许多研究的数据支持上下文处理理论的几个方面;然而，也有不可预测的结果被报道。期望AX范式的发展仍在继续，未来的发展，可能会提高其实用性也进行了描述。
Tasks developed for basic cognitive neuroscience are often ill suited for experimental psychopathology. The development of the expectancy variant of AX continuous performance task to test theories about context processing in schizophrenia is used as an illustration of how this has been done in one research program. Four design principles are recommended: tasks should (1) have a foundation in existing literature and therefore stay as close as possible to an existing task; (2) be simple, which is frequently accomplished by paring down a task to evaluate the function of interest; (3) probe a mechanism of interest, with conditions that selectively manipulate this mechanism; and (4) have the potential to distinguish a specific deficit on the mechanism of interest from a generalized impairment. Data from a number of studies support several aspects of context-processing theory; however unpredicted results have also been reported. The development of the expectancy AX paradigm continues, and future developments that may enhance its usefulness are also described.