Monitoring lesion activity on primary teeth with CP-OCT and SWIR reflectance imaging.
Monitoring lesion activity on primary teeth with CP-OCT and SWIR reflectance imaging.
复制标题
使用 CP-OCT 和 SWIR 反射成像监测乳牙上的病变活动。
DOI：
10.1002/lsm.23677
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发表时间：
2023
影响因子：
2.4
通讯作者：
Fried,Daniel
中科院分区：
文献类型：
--
作者：
Zhu,Yihua;Kim,Jungsoo;Lin,Brent;Fried,Daniel
本研究的目的是使用交叉偏振光学相干断层扫描（CP-OCT）和短波红外成像（SWIR）反射成像监测的结构和活动的变化，早期咬合龋的乳牙在6个月的干预期间与fluorine.MethodsParticipants（n= 29）6 - 10岁，每个乳牙有两个可疑的活动性咬合病变完成了研究。每3个月在牙齿表面涂抹一次氟化物保护漆，并指导参与者每天用氟化物牙膏刷牙两次。使用CP‐OCT每3个月采集一次图像，持续6个月。SWIR反射率图像在强制空气干燥的病变为30秒，在0和6-months.Results42病变最初出现活跃在基线。基于CP‐OCT图像中存在高度矿化的透明表面层（TSL），仅6处病变在基线时停止。在6个月时，14个病变出现了停滞，包括6个最初停滞的病变，TSL厚度显著增加（p< 0.0001）。对于分析的42个病变，6个月后平均病变深度（Ld）和相对于病变深度的积分反射率（ΔR）显著增加（p< 0.05）。SWIR反射率图像显示，有一个显着较高的（p< 0.05）延迟前的强度变化进行了测量活动性病变与逮捕病变病变during lesion drying.ConclusionCP-OCT能够监测病变结构和活动的变化，包括形成一个高度矿化的TSL指示病变逮捕在非手术干预。时间分辨SWIR反射率成像还显示，活动性和停滞病变之间的脱水动力学存在差异。本研究展示了两种独立的成像方法，可用于监测病变活动随时间的变化。
ObjectiveThe purpose of this study was to use cross polarization optical coherence tomography (CP‐OCT) and short wavelength infrared imaging (SWIR) reflectance imaging to monitor changes in the structure and activity of early occlusal caries on primary teeth over a period of 6 months during intervention with fluoride.MethodsParticipants (n= 29) aged 6−10 each with two suspected active occlusal lesions on primary teeth completed the study. Fluoride varnish was applied to tooth surfaces every 3‐months and participants were instructed to brush twice daily with a fluoride toothpaste. Images were acquired using CP‐OCT every 3 months for 6 months. SWIR reflectance images were acquired during forced air‐drying of the lesions for 30 s at 0 and 6‐months.ResultsMost of the 42 lesions appeared initially active at baseline. Only 6 lesions appeared arrested at baseline based on the presence of a highly mineralized transparent surface layer (TSL) in CP‐OCT images. At 6 months, 14 of the lesions appeared arrested including the 6 initially arrested lesions and the TSL thickness increased significantly (p< 0.0001). The mean lesion depth (Ld) and the integrated reflectivity over the lesion depth (ΔR) increased significantly (p< 0.05) after 6 months for the 42 lesions analyzed. SWIR reflectance images showed that there was a significantly higher (p< 0.05) delay before changes in intensity were measured for active lesions versus arrested lesions during lesion drying.ConclusionCP‐OCT was able to monitor changes in lesion structure and activity including the formation of a highly mineralized TSL indicative of lesion arrest during nonsurgical intervention. Time‐resolved SWIR reflectance imaging also shows that there are differences in the dehydration kinetics between active and arrested lesions. This study demonstrates two independent imaging methods that can be used to monitor changes in lesion activity over time.