Isolation, Characterization, and Antioxidant Activity of Bromophenols of the Marine Red Alga Rhodomela confervoides
Isolation, Characterization, and Antioxidant Activity of Bromophenols of the Marine Red Alga Rhodomela confervoides
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DOI：
10.1021/jf2022447
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发表时间：
2011-09-28
影响因子：
6.1
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
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作者：
Li, Ke;Li, Xiao-Ming;Wang, Bin-Gui
从海洋红藻红藻Rhodomela consivoids的甲醇提取物中分离和鉴定了19种天然溴酚，其中6种为新结构，13种为已知结构。经波谱鉴定为3，4-dibromo-5-((methylsulfonyl)methyl)benzene-1，2-diol(1)，3，4-dibromo-5-((2，3-dihydroxypropoxy)methyl)benzene-1，2-diol(2)，5-(氨甲基)-3，4-二溴-1，2-二醇(3)，2-(2，3-二溴-4，5-二羟基苯基)乙酸(4)，2-甲氧基-3-溴-5-羟甲基苯酚(5)和(E)-4-(2-bromo-4，5-dihydroxyphenyl)but-3-en-2-one(6)。考察了各化合物对DPPH(α，α-二苯基-β-二吡酰肼)和ABTS[2，2‘-氮杂二(3-乙基苯并噻唑啉-6-磺酸)二铵盐]自由基的清除活性。它们中的大多数都表现出比阳性对照丁基羟基甲苯(BHT)和抗坏血酸更强或相当的活性。这项研究的结果表明，红藻是天然抗氧化剂的极好来源，而包含这些富含抗氧化剂的藻类成分可能有助于防止食物的氧化变质。
A total of 19 naturally occurring bromophenols, with six new and 13 known structures, were isolated and identified from the methanolic extract of the marine red alga Rhodomela confervoides. The new compounds were identified by spectroscopic methods as 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol (1), 3,4-dibromo-5-((2,3-dihydroxypropoxy)methyl)benzene-1,2-diol (2), 5-(aminomethyl)-3,4-dibromobenzene-1,2-diol (3), 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid (4), 2-methoxy-3-bromo-5-hydroxymethylphenol (5), and (E)-4-(2-bromo-4,5-dihydroxyphenyl)but-3-en-2-one (6). Each compound was evaluated for free radical scavenging activity against DPPH (a,alpha-diphenyl-beta-dipicrylhydrazyl) and ABTS [2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt] radicals. Most of them exhibited potent activities stronger than or comparable to the positive controls butylated hydroxytoluene (BHT) and ascorbic acid. The results from this study suggest that R. confervoides is an excellent source of natural antioxidants, and inclusion of these antioxidant-rich algal components would likely help prevent the oxidative deterioration of food.