Rotavirus cell entry: not so simple after all
Rotavirus cell entry: not so simple after all
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DOI：
10.1016/j.coviro.2021.03.011
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发表时间：
2021-04-19
影响因子：
5.9
通讯作者：
Lopez, Susana
中科院分区：
文献类型：
--
作者：
Arias, Carlos F.;Lopez, Susana
轮状病毒是幼儿严重胃肠炎的重要病原体，并表现出非常选择性的细胞和组织嗜性，以及显着的年龄和宿主限制。在过去的几年中，这些特性与病毒与细胞表面上的组织血型抗原的最初相互作用有关，尽管也发现附着后相互作用决定了对人类肠类感染的易感性。这些最初的相互作用似乎也决定了病毒的进入途径，以及影响病毒细胞内囊泡运输和从内体逃逸的信号级联的诱导。在这里，我们回顾一下目前对病毒进入旅程的不同阶段的认识。
Rotaviruses are important agents of severe gastroenteritis in young children, and show a very selective cell and tissue tropism, as well as significant age and host restriction. In the last few years, these properties have been associated with the initial interaction of the virus with histo-blood group antigens on the cell surface, although post-attachment interactions have also been found to define the susceptibility to infection of human enteroids. These initial interactions seem also to determine the virus entry pathway, as well as the induction of signaling cascades that influence the virus intracellular vesicular traffic and escape from endosomes. Here we review the current knowledge of the different stages of the virus entry journey.