Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages
Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages
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DOI：
10.1128/iai.69.1.575-578.2001
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发表时间：
2001-01-01
影响因子：
3.1
通讯作者：
Macela, A
中科院分区：
文献类型：
--
作者：
Kuthejlová, M;Kopecky, J;Macela, A
蓖麻蜱唾液腺提取物抑制小鼠巨噬细胞对阿兹利螺旋体的杀伤作用。SGE还减少了吞噬细胞的两种主要防御分子，超氧化物和一氧化氮的产生。可能是抑制巨噬细胞的杀微生物机制，促成了蜱虫唾液对阿兹利螺旋体杀灭的抑制作用，从而促进了这一重要病原体的传播。
Salivary gland extract (SGE) from Ixodes ricinus ticks inhibited: the killing of Borrelia afzelii spirochetes by murine macrophages. SGE also reduced the production of two major defense molecules of phagocytes, superoxide and nitric oxide. It is likely that the suppression of macrophage microbicidal mechanisms contributes to the inhibitory effect of tick saliva on the killing of B. afzelii spirochetes, thus facilitating the transmission of this important pathogen.