C-reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase-mediated oxidative stress
C-reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase-mediated oxidative stress
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C反应蛋白通过NADPH氧化酶介导的氧化应激促进单核细胞与内皮细胞的粘附
DOI：
10.1002/jcb.23415
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发表时间：
2012-03-01
影响因子：
4
通讯作者：
Li, Jian
中科院分区：
文献类型：
--
作者：
Huang, Xiuqing;Zhang, Jing;Li, Jian
单核细胞与内皮细胞的粘附性增强是动脉粥样硬化形成的早期事件。已有研究表明，C-反应蛋白(CRP)在动脉粥样硬化形成中起关键作用。在这里，我们研究了CRP对单核细胞-内皮细胞黏附的影响，并验证了NADPH氧化酶(NOX)介导的氧化应激可能在CRP诱导的单核细胞-内皮细胞黏附中起关键作用的假说。本研究首先对36例颈动脉内膜中层增厚患者和34例正常对照进行了研究。分析血糖、血脂、C反应蛋白、单核细胞趋化蛋白-1、丙二醛和蛋白质羧化水平。结果表明，颈动脉IMT与血脂代谢异常有关，包括CRP、甘油三酯(TG)升高(P
Enhanced monocyte adhesion to endothelial cells is an early event in atherogenesis. It has been shown that C-reactive protein (CRP) plays a key role in atherogenesis. Here, we investigated the effects of CRP on monocyte-endothelial cell adhesion and tested the hypothesis that NADPH oxidase (NOX)-mediated oxidative stress might play a key role in CRP-induced monocyte-endothelial cell adhesion. Firstly, 36 patients with carotid intima-media thickness (IMT) incrassation and 34 controls were enrolled in this study. The levels of glucose, lipids, CRP, monocyte chemotractant protein (MCP-1), malondialdehyde (MDA), and protein carbonylation were analyzed. The results showed that carotid IMT was associated with abnormal lipid metabolism, including elevated CRP, triglycerides (TG) (P