Influence of serum leptin on weight and body fat growth in children at high risk for adult obesity
Influence of serum leptin on weight and body fat growth in children at high risk for adult obesity
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DOI：
10.1210/jc.2006-1390
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发表时间：
2007-03-01
影响因子：
5.8
通讯作者：
Yanovski, Jack A.
中科院分区：
文献类型：
--
作者：
Fleisch, Abby F.;Agarwal, Neha;Yanovski, Jack A.
目的：我们的目的是前瞻性地检测血清瘦素作为成人肥胖高危儿童体重和体脂增长的预测因子。我们假设瘦素测量值与脂肪组织生长增加呈正相关，因为基线瘦素高的儿童体脂量具有更大的瘦素抵抗，因此更容易体重增加。方法：从1996年开始招募6 - 12岁的儿童，这些儿童由于早发性儿童期超重和/或父母超重而具有成人肥胖的高风险，2004.在197名儿童中研究了体重指数（BMI）的增长，在149名儿童中检查了总体脂量的增长，平均随访时间为4.4年（范围，1 - 8年）。纵向分析占性别，种族，社会经济地位，初始身体成分，年龄，骨龄，和体力活动，并包括所有可用的中期访问为每个人，使总共982个主题访问被列入analysis.Results：在基线，43%的儿童研究超重（BMI >= 95 th百分位数），在后续行动中，额外的14%成为超重。独立于初始身体成分，基线瘦素是BMI增加的统计学显著正预测因子（P = 0.0147）和增加的总身体脂肪量（P < 0.007）。不依赖于体脂的高血清瘦素可能是瘦素抵抗增加的指标，这使处于成人肥胖高风险的儿童在儿童期的体重和身体脂肪的增长更快。
Objective: Our objective was to examine serum leptin prospectively as a predictor of weight and body fat growth in children at high risk for adult obesity. We hypothesized that leptin measurements would be positively associated with increased growth of adipose tissue because children with high baseline leptin for their body fat mass have greater leptin resistance and thus would have greater susceptibility to weight gain.Methods: Children ages 6 - 12 yr at high risk for adult obesity because of early-onset childhood overweight and/or parental overweight were recruited from 1996 - 2004. Growth in body mass index ( BMI) was studied in 197 children, and growth in total body fat mass was examined in 149 children over an average follow-up interval of 4.4 yr ( range, 1 - 8 yr). Longitudinal analyses accounted for sex, race, socioeconomic status, initial body composition, age, skeletal age, and physical activity and included all available interim visits for each individual so that a total of 982 subject visits were included in the analysis.Results: At baseline, 43% of children studied were overweight ( BMI >= 95th percentile); during follow-up, an additional 14% became overweight. Independent of initial body composition, baseline leptin was a statistically significant positive predictor of increased BMI ( P = 0.0147) and increased total body fat mass ( P < 0.007).Conclusions: High serum leptin, independent of body fat, may be an indicator of increased leptin resistance, which predisposes children at high risk for adult obesity to somewhat greater growth in weight and body fat during childhood.