Prostate cancer among pesticide applicators: a meta-analysis
Prostate cancer among pesticide applicators: a meta-analysis
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农药施用者中的前列腺癌：荟萃分析
DOI：
10.1007/s00420-004-0548-8
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发表时间：
2004
影响因子：
3
通讯作者：
J. Willems
中科院分区：
文献类型：
--
作者：
G. Maele;G. Maele;J. Willems
目的：分析来自同行审查、个案参照和队列研究的数据，研究农药施用者和其他一些相关职业类别中前列腺癌的发生率，以确定前列腺癌与农药接触之间的可能关系;计算元速率比，并将其与在较短时间内执行的先前元分析中获得的元速率比进行比较（1995-2001年）在更广泛的接触类别中，包括许多与农药有关的农业和非农业职业。研究方法：检索Medline 1966年至2003年期间的相关研究，并从1986年起确定相关研究。我们对符合纳入标准的22项研究进行荟萃分析，以汇总其相对风险（RR）估计值。对研究进行了总结，并评估了同质性和发表偏倚。结果：基于22个RR估计值的Meta率比为1.24 [95%置信区间（95%CI）1.06-1.45]。选定职业类别的合并风险估计数高于先前在较短的公布期内为一般农民计算的风险估计数。不同研究之间的率比存在显著异质性。确定的异质性的主要来源是地理位置。在来自北美和欧洲的研究中观察到元比率增加，欧洲的元比率低于北美。没有明显的出版偏倚迹象。结论：农业农药应用中前列腺癌的元发病率增加为农药接触与前列腺癌之间可能的关系提供了额外的证据。在我们根据地理位置对数据进行重新分组后，在个体比率之间观察到的同质性倾向于增加相关性的一致性。然而，从个别研究中获得的数据并没有提供足够的接触信息，无法得出关于农药接触是前列腺癌原因的确切结论，而不依赖于其他因素。
Objectives: To analyse data from peer-reviewed, case-referent and cohort studies, studying the occurrence of prostate cancer in pesticide applicators and in some other, related, occupational categories, in order to determine a possible relationship of cancer of the prostate with pesticide exposure; to calculate a meta-rate ratio and to compare it with the meta-rate ratios obtained in a previous meta-analysis performed over a shorter time (1995–2001) in a broader exposure category, including many pesticide-related agricultural and non-agricultural occupations. Methods: Medline was searched for the years between 1966 and 2003, and relevant studies were identified from 1986 on. We conducted a meta-analysis of 22 studies complying with the inclusion criteria in order to pool their relative risk (RR) estimates. Studies were summarised and assessed for homogeneity and publication bias. Results: The meta-rate ratio, based on 22 estimates of RR, is 1.24 [95% confidence interval (95% CI) 1.06–1.45]. This pooled risk estimate for the occupational categories selected is higher than the one previously calculated for farmers in general over a shorter period of publication. Substantial heterogeneity of rate ratios exists between the different studies. The major source of heterogeneity identified is geographic location. Increased meta-rate ratios are observed for studies derived from North America as well as from Europe, the meta-rate ratios from Europe being lower than those from North America. There is no obvious indication of publication bias. Conclusion: The increased meta-rate ratio for prostate cancer in agricultural pesticide applications provides additional evidence for a possible relationship between pesticide exposure and prostate cancer. The homogeneity observed between the individual rate ratios, after we had regrouped the data according to geographic location, tends to increase the consistency of the association. However, the data available from the individual studies do not provide sufficient exposure information for firm conclusions to be drawn about pesticide exposure as the cause of prostate cancer, independently from other factors.
影响因子：
5
作者：
Kogevinas, M;Becher, H;Saracci, R
通讯作者：
Saracci, R
影响因子：
--
作者：
Dosemeci, M;Alavanja, MCR;Blair, A
通讯作者：
Blair, A