Measurement and Modulation of Plasticity of the Motor System in Humans Using Transcranial Magnetic Stimulation
Measurement and Modulation of Plasticity of the Motor System in Humans Using Transcranial Magnetic Stimulation
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DOI：
10.1123/mcj.13.4.442
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发表时间：
2009-10-01
期刊：
影响因子：
1.1
通讯作者：
Udupa, Kaviraja
中科院分区：
文献类型：
--
作者：
Chen, Robert;Udupa, Kaviraja
几种涉及经颅磁刺激(TMS)的技术可以用来非侵入性地测量人类大脑的可塑性。其中包括配对联想刺激(PAS)、重复经颅磁刺激(RTMS)和theta爆发式刺激(TBS)。其中一些技术是基于使用依赖可塑性的原理，或者被设计来模仿动物研究中用于诱导长期增强或抑郁的方案。这些研究已经应用于某些神经和精神障碍，以调查他们的病理生理学。例如，PAS诱导的可塑性在肌张力障碍和中风患者中增强，但在亨廷顿病和精神分裂症患者中降低。此外，TMS可用于调节大脑的可塑性，并具有治疗中风、帕金森病、肌张力障碍和抑郁症等神经和精神疾病的潜力。
Several techniques that involve transcranial magnetic stimulation (TMS) can be used to measure brain plasticity noninvasively in humans. These include paired-associative stimulation (PAS), repetitive transcranial magnetic stimulation (rTMS) and theta burst stimulation (TBS). Some of these techniques are based the principle of use dependent plasticity or are designed to mimic protocols used to induce long-term potentiation or depression in animal studies. These studies have been applied to certain neurological and psychiatric disorders to investigate their pathophysiology. For example, PAS induced plasticity is enhanced in dystonia and stroke but is reduced in Huntington's disease and schizophrenia. Furthermore, TMS may be used to modulate brain plasticity and has therapeutic potential in neurological and psychiatric disorders such as stroke, Parkinson's disease, dystonia and depression.