Angiotensin II-induced tachyphylactic constrictions in isolated and perfused canine mesenteric arteries.
Angiotensin II-induced tachyphylactic constrictions in isolated and perfused canine mesenteric arteries.
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血管紧张素 II 在分离和灌注的犬肠系膜动脉中诱导快速收缩。
DOI：
10.1620/tjem.150.417
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Tsukada
中科院分区：
文献类型：
--
作者：
S. Chiba;M. Tsukada
采用不锈钢插管法观察血管紧张素II对离体和灌注的狗肠系膜动脉在吲哚美辛治疗和不治疗以及在腔内加和不加去除内皮的皂苷治疗的影响。在未处理的制剂中，血管紧张素II以10、20、30或60分钟的间隔重复给药。每一时期的血管紧张素II引起快速反应。快速反应程度的顺序为10 > 20 > 30 > 60 min。相对较大的剂量很容易引起快速反应。苯妥拉明治疗制剂不影响快速反应。吲哚美辛（5mg）处理组血管紧张素ii诱导的快速反应明显小于未处理组。在小剂量的血管紧张素II中，在大多数情况下，吲哚美辛治疗的制剂没有出现快速反应。在经1和3mg皂苷处理的去内皮细胞制剂中，引起的快速反应与未经皂苷处理的制剂相似。由此可见，前列腺素可能部分参与了血管紧张素诱导的快速反应，前列腺素可能在血管内合成，大剂量的血管紧张素II诱导的快速反应与前列腺素的产生无关。
The stainless steel cannula inserting method was used to investigate the effects of angiotensin II on isolated and perfused dog mesenteric arteries with and without indomethacin treatment, or with and without intraluminal saponin-treatment which removed the endothelium. In non-treated preparations, angiotensin II was intraluminally administered repetitively at 10, 20, 30 or 60 min inervals. Each period of angiotensin II causes tachyphylaxis. The order of degree of tachyphylaxis was 10 greater than 20 greater than 30 greater than 60 min intervals. Relatively large doses much readily caused tachyphylaxis. Tachyphylaxis was not affected by phentolamine-treatment preparations. In indomethacin (5 mg)-treated preparations, the angiotensin II-induced tachyphylaxis was significantly less than that in non-treated ones. In small doses of angiotensin II, tachyphylaxis did not appear in the majority of cases in indomethacin-treated preparations. In deendothelial preparations which were induced by intraluminal administration of saponin (1 and 3 mg), the tachyphylaxis was induced similar to non-saponin treated preparations. It is concluded that prostaglandin may partially participate in induction of angiotensin-induced tachyphylaxis, the prostaglandin may be synthesized in the inside of vasculature, and a large dose of angiotensin II induces tachyphylaxis unrelated to production of prostaglandin.
血管紧张素 II 诱导血管平滑肌松弛。
DOI：
10.1159/000158382
发表时间：
1982
期刊：
Blood vessels
影响因子：
--
作者：
Webb,RC
通讯作者：
Webb,RC