Urinary p-cresol is elevated in small children with severe autism spectrum disorder
Urinary p-cresol is elevated in small children with severe autism spectrum disorder
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DOI：
10.3109/1354750x.2010.548010
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发表时间：
2011-05-01
期刊：
影响因子：
2.6
通讯作者：
Persico, Antonio M.
中科院分区：
文献类型：
--
作者：
Altieri, Laura;Neri, Cristina;Persico, Antonio M.
一些研究描述了自闭症患者体内不寻常的肠道细菌菌株的过度生长，能够推动酪氨酸的发酵，形成对甲酚。我们比较了59对配对病例对照的尿液中对甲酚的水平，这些水平是用高效液相色谱-紫外线法测量的。8岁以下自闭症儿童尿中对甲酚含量显著升高（p < 0.01），以女性为典型（p < 0.05），且不论性别均较严重（p < 0.05）。尿可替宁测量排除了与吸烟有关的碳氢化合物污染作为这些差异的因素。因此，尿中对甲酚的升高可能是幼儿，尤其是女性和受影响更严重的男性自闭症倾向的生物标志物。
Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p < 0.01), typically females (p < 0.05), and more severely affected regardless of sex (p < 0.05). Urinary cotinine measurements excluded smoking-related hydrocarbon contaminations as contributors to these differences. Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males.