Posterodorsal septal lesions impair performance on both shift and stay working memory tasks.
Posterodorsal septal lesions impair performance on both shift and stay working memory tasks.
复制标题
后背间隔病变会损害轮班和保持工作记忆任务的表现。
DOI：
10.1037//0735-7044.98.3.405
复制
发表时间：
1984
影响因子：
1.9
通讯作者：
G. N. Brito
中科院分区：
文献类型：
--
作者：
M. Stanton;G. J. Thomas;G. N. Brito
两组大鼠术前训练的转移或停留的问题，在T-迷宫。训练试验包括两个阶段，一个是“信息阶段”，受试者被迫走下T型迷宫的两个臂中的一个，紧接着是“选择阶段”，受试者可以选择任何一个臂。在转移条件下，大鼠只会因为选择了与他们进入信息阶段相反的一个臂而得到湿糊状物的奖励。在停留条件下，大鼠因进入信息运行中输入的手臂而获得奖励。在这两种情况下，大鼠最终都学会了以100%的中位准确率进行表演，但轮班组在比停留组更少的试验后达到了这一水平。在随后的阶段中，信息运行和选择运行之间的延迟从0增加到30、60、90、210，然后减少到0秒。两组的选择准确率随着延迟的增加而下降，并在0秒延迟时恢复到100%。每种情况下有一半的受试者接受了后背隔的损伤（旨在断开间隔和腹主动脉）或对照手术。术后固位缺陷导致后背间隔病变的转移和停留条件。在术后训练中，表现有一定程度的恢复，但没有“节省”的迹象。这些结果表明，隔-海马损伤大鼠的迷宫表现缺陷并不限于需要交替空间位置的任务。这一发现否定了迷宫缺陷反映了自发交替缺陷或改变的“空间策略”的概念，但它支持了这些动物工作记忆缺陷的假设。
Two groups of rats were trained preoperatively on either a shift or a stay problem in a T-maze. Training trials consisted of two runs, an "information run" in which a subject was forced to go down one of the two arms of the T-maze, followed immediately by a "choice run" in which the subject could choose either arm. In the shift condition, rats were rewarded with wet mash only for choosing the arm opposite the one they entered on the information run. In the stay condition, rats were rewarded for entering the arm that was entered on the information run. In both conditions, rats ultimately learned to perform with median accuracy of 100%, but the shift group reached this level of performance after fewer trials than the stay group. In a subsequent phase, the delay between information runs and choice runs was increased from 0 to 30, 60, 90, 210 and then decreased back to 0 s. Choice accuracy in both groups declined as the delay increased and returned to 100% at the 0-s delay. Half of the subjects in each condition then received either lesions of the posterodorsal septum-aimed at disconnecting the septum and hippocampus-or control surgery. Postoperative retention deficits resulted from posterodorsal septal lesions in both shift and stay conditions. There was some recovery of performance but no indication of "savings" during postoperative training. These results indicate that deficits in maze performance by rats with septo-hippocampal damage are not restricted to tasks that require alternation of spatial locations. This finding falsifies the notion that maze deficits reflect a spontaneous alternation deficit or changed "spatial strategy," but it supports the hypothesis of a working memory deficit in these animals.