Medial prefrontal transection enhances social interaction - I: Behavioral studies
Medial prefrontal transection enhances social interaction - I: Behavioral studies
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DOI：
10.1016/s0006-8993(00)02931-0
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发表时间：
2000-12-22
期刊：
影响因子：
2.9
通讯作者：
Hernandez, L
中科院分区：
文献类型：
--
作者：
Gonzalez, LE;Rujano, M;Hernandez, L
在动物焦虑试验中评估了内侧前额叶皮层（MPFC）横断的行为影响。MPFC损伤动物的社会调查和+迷宫张开臂探索活动增加。MPFC病变可预防d -安非他明（2 mg/kg, i.p.）引起的社会调查减少和夸张的全身运动增加。在第二次（重复）+迷宫试验中，安定（1mg /kg, ig）和MPFC协同增加了开放臂探查。这些结果表明，MPFC可能涉及一种广泛的预警机制，使其能够对焦虑刺激产生适当的反应。虽然这种损伤本身没有改变运动活动，但安非他明引起的运动激活模式发生了改变。讨论了MPFC区域在与恐惧相关的行为反应中的作用。(C) 2000 Elsevier Science B.V.版权所有
Behavioral effects of a medial prefrontal cortex (MPFC) transection were assessed in animal tests of anxiety. Social investigation and plus-maze open arm exploration increased in MPFC damaged animals relative to sham ones. MPFC lesions prevented D-amphetamine (2 mg/kg, i.p.) induced social investigation decrease and exaggerated general locomotion increase. Diazepam (1 mg/kg, i.p.) and MPFC synergistically increased open arm exploration on a second (repeated) plus-maze trial. These results suggest that the MPFC would be implicated in a generalized mechanism of warning enabling emission of appropriate responses to anxiogenic stimuli. Although, this lesion did not modify motor activity itself, the pattern of the motor activation induced by amphetamine was altered. The role of the MPFC areas in the behavioral response associated with fear is discussed. (C) 2000 Elsevier Science B.V. All rights reserved.