ORAL-CONTRACEPTIVES AND PRIMARY LIVER-CANCER AMONG YOUNG-WOMEN
ORAL-CONTRACEPTIVES AND PRIMARY LIVER-CANCER AMONG YOUNG-WOMEN
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DOI：
10.1007/bf00051911
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发表时间：
1992-01-01
影响因子：
2.3
通讯作者：
FRAUMENI, JF
中科院分区：
文献类型：
--
作者：
HSING, AW;HOOVER, RN;FRAUMENI, JF
在一项对76例原发性肝癌死亡、22例肝内胆管癌死亡和629例对照研究中，研究人员对口服避孕药的使用与肝癌的关系进行了调查。研究对象为25岁至49岁的女性。这项研究的对象来自1986年的全国死亡率跟踪调查，其中包括向美国近2万名死者的近亲发送或管理的问卷。收集了一些生活方式因素的信息，包括关于口服避孕药使用的问题。长期服用口服避孕药者（比值比[OR] = 1.6, 95%可信区间[CI] = 0.9-2.6）和长期服用口服避孕药者（比值比[OR] = 2.0, CI = 0.8-4.8）患原发性肝癌的风险增加。当分析仅限于配偶或父母为被调查者的受试者时，长期使用者（or = 2.7, CI = 1.4-5.3）和长期使用者（or = 4.8, CI = 1.714）的风险更明显。0)。没有发现肝内胆管癌的明显超额风险。该研究是迄今为止规模最大的一项研究，增加了表明使用口服避孕药，特别是长期使用口服避孕药会增加原发性肝癌风险的调查数量。
The association of oral contraceptive use with liver cancer was examined in a study of 76 deaths from primary liver cancer, 22 deaths from cancer of the intrahepatic bile ducts, and 629 controls among women aged 25 to 49 years. The subjects in the study are from the 1986 National Mortality Followback Survey, which included a questionnaire sent or administered to the next-of-kin of almost 20,000 deceased individuals in the United States. Information on a number of lifestyle factors was collected, including questions on oral contraceptive use. Increased risks of primary liver cancer were found for ever-users (odds ratio [OR] = 1.6, 95 percent confidence interval [CI] = 0.9-2.6), and for long-term (greater-than-or-equal-to 1 0 years) users (OR = 2.0, CI = 0.8-4.8) of oral contraceptives. When the analysis was restricted to subjects whose spouse or parent was the respondent, more pronounced risks were seen for ever-users (OR = 2.7, CI = 1.4-5.3) and long-term users (OR = 4.8, CI = 1.714. 0). No clear excess risk was found for cancer of the intrahepatic bile ducts. This study, the largest to date, adds to the number of investigations demonstrating an increased risk of primary liver cancer with use, particularly long-term use, of oral contraceptives.