Fenugreek Improves Diet-induced Metabolic Disorders in Rats
Fenugreek Improves Diet-induced Metabolic Disorders in Rats
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DOI：
10.1055/s-0031-1291345
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发表时间：
2011-11
影响因子：
2.2
通讯作者：
E. Muraki;H. Chiba;N. Tsunoda;K. Kasono
中科院分区：
文献类型：
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作者：
E. Muraki;H. Chiba;N. Tsunoda;K. Kasono
摘要胡芦巴（胡芦巴）已经在前面描述过，并且其在古代医学实践中的用途是众所周知的。胡芦巴的降血糖作用已在许多动物模型和糖尿病患者中进行了研究。本研究旨在探讨胡芦巴对大鼠代谢性疾病的预防作用。本研究中使用的饮食是标准饮食、高脂肪高蔗糖（HFS）饮食和含有0.5 g/kg B的HFS饮食。w./天胡芦巴的基础上的AIN-93 G纯化饮食的修改版本，分别为12周。喂食含有胡芦巴的HFS饮食的大鼠显示出显著低于喂食HFS饮食的大鼠的空腹胰岛素水平和HOMA-IR。因此，胡芦巴改善了大鼠的胰岛素敏感性。胡芦巴组血浆中的甘油三酯和总胆固醇水平显著降低。此外，在喂食含有胡芦巴的HFS饮食的大鼠中发现肝脏中的甘油三酯、总胆固醇、游离脂肪酸和磷脂水平明显降低。这些结果表明，胡芦巴提高胰岛素敏感性，至少部分通过改善脂质代谢紊乱的血浆和肝脏中的HFS饮食诱导的大鼠。
Abstract Trigonella foenum-graecum L. (fenugreek) has been described earlier and its use in ancient medicinal practice is well known. The hypoglycemic effects of fenugreek have been studied in many animal models and diabetic patients. The purpose of this study was to examine the preventive efficiency of dietary fenugreek on diet-induced metabolic diseases in rats. The diets used in this study were a standard diet, a high-fat high-sucrose (HFS) diet, and a HFS diet containing 0.5 g/kg b. w./day fenugreek based on the modified version of the AIN-93G purified diet, for 12 weeks, respectively. The rats fed the HFS diet containing fenugreek showed significantly lower fasting insulin levels and HOMA-IR than the rats fed the HFS diet. Therefore, fenugreek improved insulin sensitivity in rats. The triglyceride and total cholesterol levels in the plasma were significantly lower in the fenugreek-administered group. Moreover, distinct reductions of triglyceride, total cholesterol, free fatty acid, and phospholipid levels in the liver were found in the rats fed the HFS diet containing fenugreek. These results suggest that fenugreek enhanced insulin sensitivity at least partly by improving lipid metabolism disorders in the plasma and the liver in the rats induced by the HFS diet.