Investigation of Plasmonic Detection of Human Respiratory Virus
Investigation of Plasmonic Detection of Human Respiratory Virus
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DOI：
10.1002/adts.202000074
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发表时间：
2020-06-08
影响因子：
3.3
通讯作者：
Yong, Ken-Tye
中科院分区：
文献类型：
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作者：
Das, Chandreyee Manas;Guo, Yan;Yong, Ken-Tye
COVID-19病毒最近被确定为一种新病毒，可引起肺炎等严重感染。这种疾病的突然爆发被认为是大流行病。鉴于这一切，开发能够以最小时间延迟检测病原体的智能生物传感器至关重要。表面等离子共振 (SPR) 生物传感器利用折射率 (RI) 变化作为传感参数。在这项工作中，根据之前关于病毒等离激元检测的实验工作中获得的实际数据，对可用于检测COVID-19病毒的SPR方案进行了详细的模拟，并将结果从早期的方案中推断出来，以预测该SPR模型的一些结果。结果表明，传统的Kretschmann配置在RI变化方面的检测限(LOD)为2E-05，在780 nm波长下的平均灵敏度为122.4 degRIU(-1)。
The COVID-19 virus has been recently identified as a new species of virus that can cause severe infections such as pneumonia. The sudden outbreak of this disease is being considered a pandemic. Given all this, it is essential to develop smart biosensors that can detect pathogens with minimum time delay. Surface plasmon resonance (SPR) biosensors make use of refractive index (RI) changes as the sensing parameter. In this work, based on actual data taken from previous experimental works done on plasmonic detection of viruses, a detailed simulation of the SPR scheme that can be used to detect the COVID-19 virus is performed and the results are extrapolated from earlier schemes to predict some outcomes of this SPR model. The results indicate that the conventional Kretschmann configuration can have a limit of detection (LOD) of 2E-05 in terms of RI change and an average sensitivity of 122.4 degRIU(-1) at a wavelength of 780 nm.