Diet and genital warts: a case-control study.
Diet and genital warts: a case-control study.
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饮食和尖锐湿疣：病例对照研究。
DOI：
10.1097/00007435-199405000-00004
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发表时间：
1994
影响因子：
3.1
通讯作者：
Daling,JR
中科院分区：
文献类型：
--
作者：
Bairati,I;Sherman,KJ;McKnight,B;Habel,LA;VandenEeden,SK;Stergachis,A;Daling,JR
背景和目的：临床观察支持免疫力受损在人乳头瘤病毒 (HPV) 感染的发展中发挥重要作用。据报道，维生素（尤其是维生素 A 和 C）的摄入以及饮酒会影响免疫反应。研究目标：研究营养风险因素（包括饮酒）与尖锐湿疣风险之间的关系。研究设计：在华盛顿州西部团体健康合作社的四个诊所的参与者中进行了一项病例对照研究。 1987年4月1日至1991年9月30日期间，共有188例诊断为尖锐湿疣的病例和245名对照者完成了半定量食物频率问卷。结果：在对社会经济指标、总能量摄入量、吸烟和性行为进行调整后，每周饮用2至4杯酒精饮料与患尖锐湿疣的风险几乎加倍有关（OR=1.9，95%置信区间[CI]= 1.0-3.6）。每周饮用五杯或更多酒精饮料与尖锐湿疣的风险关系更大（OR.= 2.4，95% CI= 1.2-5.1）。风险随着酒精饮料数量的增加而增加（P = 0.006）。通过食物频率调查问卷测量的维生素 A 和 C 摄入量不会改变尖锐湿疣的风险。结论：适度大量饮酒与尖锐湿疣风险增加相关。需要进一步的生物学和流行病学研究来解释这种关联。
Background and Objectives: Clinical observations support a substantial role for impaired immunity in the development of human papillomavirus (HPV) infections. Intake of vitamins, especially vitamins A and C, and alcohol consumption have been reported to influence immune response.Goal of the Study: To examine the relationship between nutritional risk factors, including alcohol consumption, and the risk of genital warts.Study Design: A case-control study was conducted among enrollees at four clinics of Group Health Cooperative in western Washington state. A total of 188 cases diagnosed with condyloma from April 1, 1987 to September 30, 1991 and 245 controls completed a semi-quantitative food frequency questionnaire.Results: After adjustment for socioeconomic indicators, total energy intake, smoking and sexual behavior, a weekly consumption of two to four alcoholic drinks was associated with an almost doubled risk of genital warts (OR= 1.9, 95% confidence interval [CI]= 1.0-3.6). Consuming five or more alcoholic drinks per week was even more related to the risk of genital warts (OR.= 2.4, 95% CI= 1.2-5.1). The risks tended to increase with the number of alcoholic drinks (P= 0.006). Vitamin A and C intakes as measured by a food frequency questionnaire did not alter the risk of condyloma.Conclusion: Moderately high consumption of alcohol is associated with increased risk of condyloma. Further biological and epidemiological studies are needed to explain this association.