EARLY EXPOSURE TO COWS MILK AND SOLID FOODS IN INFANCY, GENETIC PREDISPOSITION, AND RISK OF IDDM
EARLY EXPOSURE TO COWS MILK AND SOLID FOODS IN INFANCY, GENETIC PREDISPOSITION, AND RISK OF IDDM
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DOI：
10.2337/diabetes.42.2.288
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发表时间：
1993-02-01
期刊：
影响因子：
7.7
通讯作者：
HAMMAN, RF
中科院分区：
文献类型：
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作者：
KOSTRABA, JN;CRUICKSHANKS, KJ;HAMMAN, RF
采用病例对照研究设计，我们检验了早期接触牛奶和固体食物增加患胰岛素依赖型糖尿病风险的假设。婴儿饮食史收集自科罗拉多胰岛素依赖型糖尿病登记处的164例平均出生年份为1973年的胰岛素依赖型糖尿病受试者和145例非糖尿病人群对照受试者，这些受试者在年龄、性别和种族上与糖尿病受试者频率匹配。早期暴露定义为3个月龄之前发生的暴露。在控制了种族、出生顺序和家庭收入后，与对照组相比，更多的糖尿病受试者早期接触牛奶（OR 4.5，95% CI 0.9-21.4）和固体食物（OR 2.5，CI 1.4-4.3）。为了研究这种关联，同时考虑到对胰岛素依赖型糖尿病的遗传易感性，我们通过HLA-DQB 1分子标记将个体定义为高风险和低风险。早期接触牛奶与低风险个体的胰岛素依赖型糖尿病风险升高无关。相对于未暴露的低风险个体，早期接触牛奶与高风险标志物的个体密切相关（OR 11.3，Cl 1.2-102.0）。早期接触固体食物也观察到类似的结果。这些数据表明，早期接触牛奶和固体食物可能与胰岛素依赖型糖尿病的风险增加有关。在分析中纳入HLA编码的风险表明遗传和环境因素的综合影响。
Using a case-control study design, we examined the hypothesis that early exposure to cow's milk and solid foods increased the risk of IDDM. An infant diet history was collected from 164 IDDM subjects from the Colorado IDDM Registry with a mean birth year of 1973, and 145 nondiabetic population control subjects who were frequency matched to diabetic subjects on age, sex, and ethnicity. Early exposure was defined as exposure occurring before 3 mo of age. After controlling for ethnicity, birth order, and family income, more diabetic subjects were exposed early to cow's milk (OR 4.5, 95% Cl 0.9-21.4) and solid foods (OR 2.5, Cl 1.4-4.3) than control subjects. To examine this association while accounting for the genetic susceptibility to IDDM, we defined individuals as high and low risk by an HLA-DQB1 molecular marker. Early exposure to cow's milk was not associated with elevated risk for IDDM in low-risk individuals. Relative to unexposed low-risk individuals, early exposure to cow's milk was strongly associated in individuals with a high risk marker (OR 11.3, Cl 1.2-102.0). Similar findings were observed for early exposure to solid foods. These data indicate that early exposure to cow's milk and solid foods may be associated with increased risk of IDDM. The inclusion of HLA-encoded risk in the analyses demonstrates the combined effect of genetic and environmental factors.